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Hemoglobin components in patients with diabetes mellitus.
Abstract An increase in a minor hemoglobin component closely resembling hemoglobin AIc in which one or more hexoses are bound to the beta-polypeptide chains was observed in a previous study ofExpand
Bimane fluorescent labels: labeling of normal human red cells under physiological conditions.
The bimane fluorescent labels, monobromobimane, dibromobimane, and monobromotrimethylammoniobimane, are derivatives of syn-9,10-dioxabimane:1,5-diazabicyclo[3.3.0]octa-3,6-diene-2,8-dione. TheyExpand
In 1966, a profound hereditary hypochromic microcytic anemia was described in the offspring of an irradiated albino rat' in Belgrade, Yugoslavia. The affected animals were retarded in growth, andExpand
Genetic epidemiology of structural mutations of the beta-globin gene.
The present article will be concerned with the epidemiological and other implications of studies of the DNA haplotypes associated with the common structural mutations of the β globin gene
Interaction of hemoglobin with red blood cell membranes as shown by a fluorescent chromophore.
Hemoglobin quenching of the fluorescence intensity of 12-(9-anthroyl)stearic acid (AS) embedded in the red blood cell membrane occurs through an energy transfer mechanism and can be used to measureExpand
Muscle phosphofructokinase deficiency.
The clinical hallmarks of muscle phosphorylase deficiency (McArdle's disease) are muscle cramps and exercise intolerance, contracture following ischemic work, and episodic myoglobinuria. We haveExpand
Studies of an unusual hemoglobin in patients with diabetes mellitus.
The properties of an unusual hemoglobin found in patients with diabetes mellitus resembled those of hemoglobin A1c prepared from normal subjects. A two-fold increase of hemoglobin A1c was found inExpand
Association of hemoglobin C with erythrocyte ghosts.
The interaction of hemoglobin C (Hb C) with erythrocyte membranes was studied using changes in fluorescence intensity in a membrane-embedded probe. The affinity of Hb C for the membranes at pH 6.0Expand
Growth of Plasmodium falciparum in human erythrocytes containing abnormal membrane proteins.
To evaluate the role of erythrocyte (RBC) membrane proteins in the invasion and maturation of Plasmodium falciparum, we have studied, in culture, abnormal RBCs containing quantitative or qualitativeExpand
Some clinical, biochemical and genetic observations on hemoglobin C.