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SYFPEITHI: database for MHC ligands and peptide motifs
- H. Rammensee, J. Bachmann, N. Emmerich, O. A. Bachor, S. Stevanović
- 30 October 1999
Abstract The first version of the major histocompatibility complex (MHC) databank SYFPEITHI: database for MHC ligands and peptide motifs, is now available to the general public. It contains a…
Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
Each MHC class I allele has its individual rules to which peptides presented in the groove adhere, and this information about the contents of MHC grooves is now provided.
MHC ligands and peptide motifs: first listing
A compendium of major histocompatibility complex (MHC) peptide motifs and MHC ligands known to date, together with a discussion of the methods used to gain this information, is provided.
Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens
Tumour-specific mutant proteins are identified as a major class of T-cell rejection antigens following anti-PD-1 and/or anti-CTLA-4 therapy of mice bearing progressively growing sarcomas, and it is shown that therapeutic synthetic long-peptide vaccines incorporating these mutant epitopes induce tumour rejection comparably to checkpoint blockade immunotherapy.
The Endoplasmic Reticulum-resident Heat Shock Protein Gp96 Activates Dendritic Cells via the Toll-like Receptor 2/4 Pathway*
The results provide the molecular basis for understanding the Gp96-mediated activation of antigen-presenting cells by describing the simultaneous stimulation of the innate and adaptive immune system.
Exact prediction of a natural T cell epitope
- O. Rötzschke, K. Falk, S. Stevanović, G. Jung, P. Walden, H. Rammensee
- BiologyEuropean journal of immunology
- 1 November 1991
It is shown that exact prediction of natural T cell epitopes is possible and predicted the natural Kb‐restricted epitope of ovalbumin, thought to be contained in the 19‐mer IINFEKLTEWTSSNVMEER, to be SIinFEKL.
Two new proteases in the MHC class I processing pathway
The data provide evidence for the existence of redundant systems acting downstream of the proteasome in the antigen-processing pathway for MHC class I molecules.
Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia.
It is reported that leukemia cells from patients variously express MIC and ULBP molecules on the cell surface with MICA most frequently detected, and determination of sMICA and sMICB levels may be implemented as a prognostic parameter in patients with hematopoietic malignancies.
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
Among six predefined populations of myeloid-derived suppressor cells, two were prognostic for overall survival, and among over 300 serum biomarkers, apolipoprotein A-I (APOA1) and chemokine (C-C motif) ligand 17 (CCL17) as being predictive for both immune response to IMA901 and overall survival are identified.
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
This work identifies and characterize multiple dominant and subdominant SARS-CoV-2 HLA class I and HLA-DR peptides as potential T cell epitopes in COVID-19 convalescent and unexposed individuals to enable identification of heterologous and post-infectious T cell immunity and facilitate development of diagnostic, preventive and therapeutic measures for CO VID-19.