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Distribution of the carbonic anhydrase isoenzymes I, II, and VI in the human alimentary tract.
The distribution of carbonic anhydrase isoenzymes I, II, and VI was studied in the human alimentary tract using specific antibodies to human isoenzymes in conjunction with the immunoperoxidaseExpand
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Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients.
Tamoxifen-induced DNA adducts were analyzed with the (32)P-postlabeling method using high-performance liquid chromatography (HPLC)-radioactivity detection from endometrial tissue of breast cancerExpand
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Tamoxifen-induced DNA adducts in leucocytes of breast cancer patients.
Tamoxifen-induced DNA adducts were searched in leucocyte DNA from breast cancer patients. Total white blood cell DNA from tamoxifen-treated and control patients was analysed by 32P-postlabellingExpand
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Dna adducts, mutations, and cancer 2000.
The main achievements in the DNA adduct field in the 1990s have been technical innovations of methods for specific adducts reaching sensitivities required for low levels encountered in humans. OverExpand
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Identification of the major tamoxifen-DNA adducts in rat liver by mass spectroscopy.
We present here the first mass spectroscopic (MS) identification of the main tamoxifen-induced DNA adducts in rat liver. The two main adducts were isolated by high-performance liquid chromatographyExpand
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Carbonic anhydrase II in the cerebrospinal fluid: its value as a disease marker
Carbonic anhydrase (CA) II is the predominant CA isoenzyme in the brain of mammals. We have recently developed a dual‐label time‐resolved immunofluorometric assay to quantify minute amounts of CA IExpand
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DNA binding of tamoxifen and its analogues: identification of the tamoxifen-DNA adducts in rat liver.
DNA binding of tamoxifen and some structurally-related drugs (toremifene, clomiphene, triparanol and raloxifene) in rat liver was studied using the 32P-postlabelling method. As only tamoxifen wasExpand
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Analysis of tamoxifen-induced DNA adducts by 32P-postlabelling assay using different chromatographic techniques.
DNA isolated from livers of rats receiving tamoxifen was analysed by the 32P-postlabelling method. The postlabelled DNA hydrolysis mixture was analysed both by reversed-phase HPLC with 32P on-lineExpand
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Characterization of the major DNA adducts in the liver of rats chronically exposed to tamoxifen for 18 months.
Our previous study has shown that chronic exposure to tamoxifen (TAM) induced formation of high levels of DNA adducts in the liver, the target tissue of TAM-induced carcinogenesis in rats. One of theExpand
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DNA adduct formation by tamoxifen and structurally-related compounds in rat liver.
Binding of diethylstilbestrol and four different triphenylethylene derivatives: tamoxifen, toremifene, clomiphene and triparanol to DNA in rat liver, was studied using the 32P-postlabelling methodExpand
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