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Pathologic correlates of incidental MRI white matter signal hyperintensities
TLDR
The histopathologic changes associated with incidental white matter signal hyperintensities on MRIs from 11 elderly patients are related to a descriptive classification for such abnormalities, and this classification appears to reflect both the different etiologies and severities of incidental MRI signal abnormalities, if it is modified to treat irregular periventricular and confluent deep white matter hyperintENSities together. Expand
The morphologic correlate of incidental punctate white matter hyperintensities on MR images.
TLDR
The results suggest minor perivascular damage but not infarction as the most likely substrate of punctate MR white matter hyperintensities in elderly brains. Expand
Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.
TLDR
It is indicated that LPL is rate limiting for the supply of muscle tissue with triglyceride-derived FFA, which may be important in the pathogenesis of some human myopathies. Expand
Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo.
TLDR
In conclusion, it appears that inactive LPL can act in vivo to mediate VLDL removal from plasma and uptake into tissues in which it is expressed. Expand
Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase.
TLDR
Findings reveal marked alterations in AT metabolism that occur during LPL deficiency and provide strong evidence for a role of AT LPL in one type of genetic obesity. Expand
Massive injury to the heart after attempted active compression-decompression cardiopulmonary resuscitation
TLDR
The autopsy revealed that death was due to myocardial infarction complicated by rupture of the infarcted area and pericardial tamponade was diagnosed, adding to the suspicion of an increased risk of cardiac injuries when using an ACD device for cardiac massage. Expand
Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance
TLDR
Total LPL deficiency in the mouse prevents triglyceride removal from plasma, causing death in the neonatal period, and expression of LPL in a single tissue alleviates this problem, supporting the contention that hypertriglyceridemia caused the death of these mice and that LPL expression in asingle tissue was sufficient for rescue. Expand
Inactive Lipoprotein Lipase (LPL) Alone Increases Selective Cholesterol Ester Uptake in Vivo, Whereas in the Presence of Active LPL It Also Increases Triglyceride Hydrolysis and Whole Particle
TLDR
In the presence of active LPL in the same tissue, inactive LPL augments triglyceride hydrolysis and increases whole particle triglyceride-rich lipoprotein and selective cholesterol ester uptake. Expand
Muscle-specific overexpression of lipoprotein lipase in transgenic mice results in increased alpha-tocopherol levels in skeletal muscle.
TLDR
The transgenic model presented in this report provides evidence that the uptake of alpha-TocH in muscle is directly dependent on the level of LPL expression in vivo and might protect the myocyte from oxidative damage during increased beta-oxidation. Expand
Muscle-specific overexpression of human lipoprotein lipase in mice causes increased intracellular free fatty acids and induction of peroxisomal enzymes.
TLDR
The results imply that improper regulation of muscle LPL leading to increased fatty acid levels in muscle can cause severe pathological changes, and suggests that FFA play an important role in the induction of these organelles. Expand
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