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Muscarinic cholinoceptors in the human heart: demonstration, subclassification, and distribution
SummaryIn human atrial and ventricular myocardium, the muscarinic cholinoceptor (M-cholinoceptor) populations were characterized by means of radioligand binding (with [N-methyl-3H]-scopolamineExpand
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Presynaptic β2-adrenoceptors on the sympathetic nerve fibres of the human saphenous vein: no evidence for involvement in adrenaline-mediated positive feedback loop regulating noradrenergic
SummarySpirally cut strips of human saphenous veins preincubated with 3H-noradrenaline were superfused in the presence of corticosterone and, unless stated otherwise, of cocaine or desipramine.Expand
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Lack of inotropic effects of neuropeptide Y in human myocardium.
The sympathetic co-transmitter neuropeptide Y (NPY) inhibits cardiac contractility in vivo in the rat heart. We tested whether NPY alters the force of contraction or the activity of adenylate cyclaseExpand
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Lack of effect of chronic calcium antagonist treatment on beta 1- and beta 2-adrenoceptors in right atria from patients with or without heart failure.
1. We studied the effects of chronic calcium antagonist (calcium entry blocker, CEB; nifedipine, verapamil, diltiazem) treatment on beta-adrenoceptor density (assessed by (-)-[125I]-iodocyanopindololExpand
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The role of cyclic AMP in the positive inotropic effect mediated by β1- and β2-adrenoceptors in isolated human right atrium
SummaryThe time course of the effects of isoprenaline (3 × 10−7 mol/l) on contractile force and on the cyclic AMP level was studied in the electrically driven isolated muscle strip of the human rightExpand
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Differential regulation of human cardiac beta-adrenergic and muscarinic receptors by chronic beta-adrenoceptor antagonist treatment.
In patients undergoing coronary artery bypass grafting chronic beta 1-adrenoceptor antagonist treatment increased right atrial beta 1-adrenoceptor number, did not affect beta 2-adrenoceptor numberExpand
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APACHE-ll-score-based identification of an escalating systemic inflammatory response syndrome (SIRS) early after cardiac surgery with the assistance of the cardiopulmonary bypass (CPB)
Multiorgan dysfunction syndrome (MODS), sepsis and septic shock are the leading causes of death in the postoperative phase after cardiac surgery assisted by the cardiopulmonary bypass (CPB). TheExpand
The cardiopulmonary bypass supported high-risk PTCA (CPB-PTCA): a useful model for the study of CPB-dependent systemic inflammatory response syndrome (SIRS)?
The mechanisms underlying myocardial depression following open heart surgery with extracorporeal circulation is still a matter of debate. One important trigger mechanism responsible for myocardialExpand
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Herzchirurgie beim alten Patienten
Herzoperationen bei betagten Patienten werden heutzutage infolge Standardisierung und Risikominimierung in der Herzchirurgie in zunehmender Anzahl durchgeführt. In Basel beträgt der Anteil der überExpand
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