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Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis
Rationale: Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous system (CNS). The function of platelets in… Expand
Recent developments in low molecular weight complement inhibitors.
As a key part of the innate immune system, complement plays an important role not only in defending against invading pathogens but also in many other biological processes. Inappropriate or excessive… Expand
PMX-53 as a Dual CD88 Antagonist and an Agonist for Mas-Related Gene 2 (MrgX2) in Human Mast Cells
- H. Subramanian, Sakeen W. Kashem, Sarah J. Collington, H. Qu, J. Lambris, H. Ali
- Biology, Medicine
- Molecular Pharmacology
- 1 June 2011
Human mast cells express the G protein coupled receptor (GPCR) for C5a (CD88). Previous studies indicated that C5a could cause mast cell degranulation, at least in part, via a mechanism similar to… Expand
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis.
Thrombosis is a common complication of end-stage renal disease, particularly in patients on hemodialysis. Although substantial progress has been made in preventing thrombotic complications in various… Expand
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties.
Therapeutic modulation of the complement system has become increasingly important in line with the growing recognition of the role of complement in numerous diseases. Compstatin, a peptidic inhibitor… Expand
Novel analogues of the therapeutic complement inhibitor compstatin with significantly improved affinity and potency.
Compstatin is a 13-residue disulfide-bridged peptide that inhibits a key step in the activation of the human complement system. Compstatin and its derivatives have shown great promise for the… Expand
The clinical value of in vivo confocal microscopy for diagnosis of ocular surface squamous neoplasia
PurposeTo determine the reliability and efficiency of in vivo confocal microscopy for the diagnosis of ocular surface squamous neoplasia (OSSN).MethodsA case series with five consecutive cases of… Expand
C5aR‐antagonist significantly reduces the deleterious effect of a blunt chest trauma on fracture healing
- S. Recknagel, R. Bindl, +9 authors A. Ignatius
- Journal of orthopaedic research : official…
- 1 April 2012
Confirming clinical evidence, we recently demonstrated that a blunt chest trauma considerably impaired fracture healing in rats, possibly via the interaction of posttraumatic systemic inflammation… Expand
Influence of loss on linearity of microring-assisted Mach-Zehnder modulator.
The microring-assisted (MRA) Mach-Zehnder (MZ) modulator offers a potential solution to attaining highly linear optical modulators. In this paper, the influence of waveguide loss on the linearity… Expand
Etched-Diffraction-Grating-Based Planar Waveguide Demultiplexer on Silicon-on-Insulator
An optical wavelength demultiplexer with the etched diffraction grating (EDG) on the silicon-on-insulator (SOI) material is demonstrated. Fabricated by the wet-anisotropic-etching method, 90° turning… Expand