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Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway
TLDR
It is found that zerumbone was able to induce apoptosis of pancreatic carcinoma cell lines, indicating to be a promising treatment for pancreatic cancer. Expand
Association study between methylenetetrahydrofolate reductase gene polymorphisms and Graves' disease
TLDR
Epidemiological evidence that MTHFR mutation (C677T) protects women from Graves' disease is provided, and the protective effect, possibly obtained by influencing DNA methylation, should be confirmed in a large number of cohorts. Expand
Detection of type 2 diabetes related modules and genes based on epigenetic networks
TLDR
The study of T2D epigenetic networks provides a new way for understanding the pathogenic mechanism of T1D caused by epigenetic disorders and detects the potential interplay modules of DNA methylation and chromatin modifications for T2d. Expand
Genetic variants of TCF7L2 are associated with type 2 diabetes in a northeastern Chinese population.
TLDR
Taken together, TCF7L2 may be an important susceptibility gene for T2D in some Chinese populations, and the discrepancies in the allelic associations determined for northern vs. southern Chinese allude to the presence of genetic variation among the Han Chinese. Expand
Affection of Single-Nucleotide Polymorphisms in miR-27a, miR-124a, and miR-146a on Susceptibility to Type 2 Diabetes Mellitus in Chinese Han People
TLDR
The rs531564GC genotype acted as a protective factor to decrease the risk of T2DM in younger subjects (age < 45 years), while the presence of the rs895819CC genotype increased the riskOf illness among overweight subjects (24 ⩽ BMI < 28 kg/m2). Expand
CXCL12 methylation-mediated epigenetic regulation of gene expression in papillary thyroid carcinoma
TLDR
This study was the first to perform an RRBS analysis for PTC and suggested that CXCL12 may contribute to PTC development by methylation-mediated epigenetic regulation of gene expression. Expand
Dynamic monitoring of circulating microRNAs as a predictive biomarker for the diagnosis and recurrence of papillary thyroid carcinoma
Circulating microRNAs (miRNAs/miRs) are considered to be potential biomarkers for numerous types of cancer. However, previous investigations into the expression of miRNAs in the serum of patientsExpand
Prioritizing cancer-related genes with aberrant methylation based on a weighted protein-protein interaction network
TLDR
Here it is shown that network theory combined with epigenetic characteristics provides a favorable platform from which to identify cancer-related genes. Expand
Homeostasis model assessment of insulin resistance in relation to the poor functional outcomes in nondiabetic patients with ischemic stroke
TLDR
High HOMA-IR index is associated with a poor functional outcome in nondiabetic patients with acute ischemic stroke and the adjusted risk of poor outcome increased. Expand
The Gas6 gene rs8191974 and Ap3s2 gene rs2028299 are associated with type 2 diabetes in the northern Chinese Han population.
TLDR
It is shown that SNPsrs8191974 and rs2028299 are significantly associated with T2DM in the Chinese population. Expand
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