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The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases
A family of H3K4me3 demethylases are identified and a critical link between histone modifications and XLMR is uncovered, uncovering a role for SMCX in neuronal survival and dendritic development and a link to the demethylase activity. Expand
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases
Insight is provided into how an activating histone mark, in combination with linked repressive marks, is differentially 'read' by two related human demethylases, PHF8 and KIAA1718. Expand
A YY1–INO80 complex regulates genomic stability through homologous recombination–based repair
  • Su Wu, Y. Shi, +9 authors Yang Shi
  • Biology, Medicine
  • Nature Structural &Molecular Biology
  • 18 November 2007
Functional assays revealed that both YY1 and INO80 are essential in homologous recombination–based DNA repair (HRR), which was further supported by the finding that YY 1 preferentially bound a recombination-intermediate structure in vitro. Expand
Histone H 4 K 20 / H 3 K 9 demethylase PHF 8 regulates zebrafish brain and craniofacial development
X-linked mental retardation (XLMR) is a complex human disease that causes intellectual disability. Causal mutations have been found in approximately 90 X-linked genes; however, molecular andExpand
Prolyl 4-hydroxylation regulates Argonaute 2 stability
Hydroxylation is identified as a post-translational modification important for Ago2 stability and effective RNA interference. Expand
Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets.
Akt3-mediated phosphorylated Argonaute 2 is a molecular switch between target mRNA cleavage and translational repression activities of Ago2, and Akt3 coimmunoprecipitates with Ago2 and phosphorylation of Ago1 facilitates its interaction with GW182 and localization to cytoplasmic processing bodies (P bodies), where miRNA-targeted mRNAs are thought to be stored and degraded. Expand
The XLMR gene PHF8 encodes a histone H4K20/H3K9 demethylase and regulates zebrafish brain and craniofacial development
Genetic and molecular evidence supports a model whereby PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways. Expand
Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins
It is shown that passenger strand cleavage and RNA chaperone activities that are intrinsic to both AGO1 and AGO2 are sufficient for RNA-induced silencing complex (RISC) loading. Expand
Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2
This study identifies hypoxia as a mediator of the miRNA-dependent gene silencing pathway through posttranslational modification of Ago2, which might be responsible for cell survival or pathological responses under low oxygen stress. Expand
Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity
It is shown that the high-mobility group transcription factors Tcf1 and Lef1 are essential for repressing CD4+ lineage–associated genes including Cd4, Foxp3 and Rorc in CD8+ T cells. Expand