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Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase
Peptidyl-tRNA hydrolase (Pth) cleaves the ester bond between the peptide and the tRNA of peptidyl-tRNA molecules, which are produced by aborted translation, to recycle tRNA for further rounds of… Expand
Biomarker detection for disease diagnosis using cost-effective microfluidic platforms.
Early and timely detection of disease biomarkers can prevent the spread of infectious diseases, and drastically decrease the death rate of people suffering from different diseases such as cancer and… Expand
In vitro spatially organizing the differentiation in individual multicellular stem cell aggregates
Abstract With significant potential as a robust source to produce specific somatic cells for regenerative medicine, stem cells have attracted increasing attention from both academia and government.… Expand
Block copolymer crystalsomes with an ultrathin shell to extend blood circulation time
In water, amphiphilic block copolymers (BCPs) can self-assemble into various micelle structures depicting curved liquid/liquid interface. Crystallization, which is incommensurate with this curved… Expand
Genome-wide landscape of position effects on heterogeneous gene expression in Saccharomyces cerevisiae
BackgroundIntegration of heterogeneous genes is widely applied in synthetic biology and metabolic engineering. However, knowledge about the effect of integrative position on gene expression remains… Expand
Ribosomal protein S1 is not essential for the trans-translation machinery.
In eubacteria, ribosome stalling during protein synthesis is rescued by a tmRNA-derived trans-translation system. Because ribosomal protein S1 specifically binds to tmRNA with high affinity, it is… Expand
Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs.
- Fumiki Yanagawa, H. Kaji, +5 authors A. Khademhosseini
- Medicine, Materials Science
- Journal of biomedical materials research. Part A
- 1 April 2011
The organization of cells within a well-defined microenvironment is important in generating the resulting tissue function. However, the cellular organization within biodegradable scaffolds often does… Expand
Engineering physical microenvironment for stem cell based regenerative medicine.
Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of… Expand
Precise control of SCRaMbLE in synthetic haploid and diploid yeast
Compatibility between host cells and heterologous pathways is a challenge for constructing organisms with high productivity or gain of function. Designer yeast cells incorporating the Synthetic… Expand
Solvent-Controlled Phase Transition of a CoII -Organic Framework: From Achiral to Chiral and Two to Three Dimensions.
An unprecedented reversible dynamic transformation is reported in a metal-organic framework involving bond formation, which is accompanied by two important structural changes; achiral to chiral and… Expand