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Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine
Objectives: The purpose of this pharmacokinetic study was to investigate the dose-dependent inhibition of model substrates for CYP2D6, CYP2C19 and CYP1A2 by four marketed selective serotonin reuptakeExpand
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Fluvoxamine is a potent inhibitor of cytochrome P4501A2.
Fluvoxamine is a new antidepressant and selectively inhibits serotonin reuptake (SSRI). The present study demonstrates that fluvoxamine is a very potent inhibitor of the high-affinity O-deethylationExpand
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Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation.
BACKGROUND Patients with atrial fibrillation (AF) often require anticoagulation and platelet inhibition, but data are limited on the bleeding risk of combination therapy. METHODS We performed aExpand
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Cancer risk and oxidative DNA damage in man
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Exposure to selective serotonin reuptake inhibitors and the risk of congenital malformations: a nationwide cohort study
Objectives To analyse the relation between selective serotonin reuptake inhibitor (SSRI) use and major congenital malformations, with focus on malformations of the heart. Design Register-basedExpand
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Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells?
The most commonly measured marker of oxidative DNA damage is 8-oxo-7,8-dihydroguanine (8-oxoGua) or its deoxyribonucleoside (8-oxodGuo). Published estimates of the concentration of 8-oxoGua/8-oxodGuoExpand
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The Effect of Polyphenols in Olive Oil on Heart Disease Risk Factors
The authors studied virgin olive oil (high in polyphenols), refined olive oil (low in polyphenols), and a mixture of the 2 oils in equal parts. Two hundred healthy young men consumed 25 mL of an ol...
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Occurrence of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Patients Is Associated with the Oxidative Stress Caused by Chronic Lung Inflammation
ABSTRACT Oxidative stress caused by chronic lung inflammation in patients with cystic fibrosis (CF) and chronic lung infection with Pseudomonas aeruginosa is characterized by the reactive oxygenExpand
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Oxidative DNA damage in human sperm influences time to pregnancy.
BACKGROUND Oxidative stress and related DNA damage in human sperm may be important for fecundity and pregnancy outcome. METHODS We studied the level of oxidative DNA damage in terms ofExpand
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Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials
In contrast to the promised ‘antioxidant miracle’ of the 1980s, several randomised controlled trials have shown no effect of antioxidant supplements on hard endpoints such as morbidity and mortality.Expand
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