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Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine
TLDR
This investigation confirms that paroxetine and fluxetine are potent inhibitors of CYP2D6, that fluvoxamine and fluoxettine are moderate inhibitors of CyP2C19 and that fluVoxamine is a potent inhibitor of CYp1A2 in humans in vivo.
Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation.
TLDR
In patients with AF, all combinations of warfarin, aspirin, and clopidogrel are associated with increased risk of nonfatal and fatal bleeding.
Cancer risk and oxidative DNA damage in man
Clinical Relevance of Biomarkers of Oxidative Stress
TLDR
It is important to realize that oxidative stress is a nuanced phenomenon that is difficult to characterize, and one biomarker is not necessarily better than others, and the vast diversity in oxidative stress between diseases and conditions has to be taken into account when selecting the most appropriate biomarker.
Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis
TLDR
The ASAP study was a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis and the results confirmed the importance of knowing the carrier and removal status of these vitamins.
Exposure to selective serotonin reuptake inhibitors and the risk of congenital malformations: a nationwide cohort study
TLDR
Risks of congenital malformations of the heart were similar for pregnancies exposed to an SSRI throughout the first trimester and for pregnancies with paused SSRI treatment during pregnancy, and the authors found no association with dosage.
Occurrence of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Patients Is Associated with the Oxidative Stress Caused by Chronic Lung Inflammation
TLDR
The results suggest that the chronic PMN inflammation in the CF lung promotes oxidative stress and is associated with the occurrence of hypermutable bacteria in the lung, which can associate with mutations that confer adaptation of the bacteria inThe lung and persistence of the infection.
Prevalence of Antidepressant Use during Pregnancy in Denmark, a Nation-Wide Cohort Study
TLDR
In spite of uncertainty concerning antidepressants’ safety during pregnancy, there is a 16-fold increase in exposure rates between 1997 and 2010 and a sharp decrease in exposure during pregnancy that is probably caused by physicians’ hesitation to prescribe antidepressants and women’s fear of unwanted effects on the unborn child.
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