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Genetic analyses from ancient DNA.
About 20 years ago, DNA sequences were separately described from the quagga (a type of zebra) and an ancient Egyptian individual. What made these DNA sequences exceptional was that they were derivedExpand
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Ancient DNA: Do It Right or Not at All
At the recent 5th International Ancient DNA Conference in Manchester, U.K., reported by Erik Stokstad in his News Focus article “Divining diet and disease from DNA” (28 Jul., p. [530][1]), oneExpand
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Antibiotic resistance is ancient
The discovery of antibiotics more than 70 years ago initiated a period of drug innovation and implementation in human and animal health and agriculture. These discoveries were tempered in all casesExpand
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A draft genome of Yersinia pestis from victims of the Black Death
Technological advances in DNA recovery and sequencing have drastically expanded the scope of genetic analyses of ancient specimens to the extent that full genomic investigations are now feasible andExpand
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Amino Acid Racemization and the Preservation of Ancient DNA
The extent of racemization of aspartic acid, alanine, and leucine provides criteria for assessing whether ancient tissue samples contain endogenous DNA. In samples in which the D/L ratio of asparticExpand
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Molecular coproscopy: dung and diet of the extinct ground sloth Nothrotheriops shastensis.
DNA from excrements can be amplified by means of the polymerase chain reaction. However, this has not been possible with ancient feces. Cross-links between reducing sugars and amino groups were shownExpand
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Metagenomics to Paleogenomics: Large-Scale Sequencing of Mammoth DNA
We sequenced 28 million base pairs of DNA in a metagenomics approach, using a woolly mammoth (Mammuthus primigenius) sample from Siberia. As a result of exceptional sample preservation and the use ofExpand
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Unreliable mtDNA data due to nuclear insertions: a cautionary tale from analysis of humans and other great apes
Analysis of mitochondrial DNA sequence variation has been used extensively to study the evolutionary relationships of individuals and populations, both within and across species. So ubiquitous andExpand
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Shotgun Mitogenomics Provides a Reference Phylogenetic Framework and Timescale for Living Xenarthrans
Xenarthra (armadillos, sloths, and anteaters) constitutes one of the four major clades of placental mammals. Despite their phylogenetic distinctiveness in mammals, a reference phylogeny is stillExpand
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A molecular analysis of ground sloth diet through the last glaciation
DNA was extracted from five coprolites, excavated in Gypsum Cave, Nevada and radiocarbon dated to approximately 11 000, 20 000 and 28 500 years bp. All coprolites contained mitochondrial DNAExpand
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