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Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity.
These findings enable bioengineering of the acyl-CoA carboxylase (ACCase) substrate specificity to provide novel extender units for the combinatorial biosynthesis of polyketides.
Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor.
- A. Arabolaza, Mary Elizabeth Shillito, +6 authors S. Tsai
- Chemistry, MedicineBiochemistry
- 31 August 2010
The first committed step of fatty acid and polyketides biosynthesis, the biotin-dependent carboxylation of an acyl-CoA, is catalyzed by acyl-CoA carboxylases (ACCases) such as acetyl-CoA carboxylase…
Calcium regulation of calmodulin binding to and dissociation from the myo1c regulatory domain.
- Slobodanka Manceva, Tianming Lin, H. Pham, John H. Lewis, Y. Goldman, E. Ostap
- Biology, MedicineBiochemistry
- 23 October 2007
The data suggest that the calmodulin bound to the IQ motif adjacent to the motor domain is rapidly exchangeable in the presence of calcium and is responsible for regulation of myo1c ATPase and motile activity.
Bactericidal Activity of Glycinecin A, a Bacteriocin Derived from Xanthomonas campestris pv. glycines, on Phytopathogenic Xanthomonas campestris pv. vesicatoria Cells
- H. Pham, Key Zoung Riu, Kong Man Jang, S. Cho, M. Cho
- Medicine, BiologyApplied and Environmental Microbiology
- 1 August 2004
The results suggest that the bactericidal mechanism of action of glycinecin A is correlated with the permeability of membranes to hydroxyl and potassium ions, leading to the lethal activity of the bacteriocin on the target bacteria.
Engineering the substrate specificity and catalysis from crystal structures of the beta-subunit of acyl-CoA carboxylase
Propionyl-CoA Carboxylase Beta Subunit, D422A
Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #3
Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #2, mutant D422I
Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #1
Biotin and propionyl-CoA bound to Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB)