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Phenolic compounds from Viscum album tinctures enhanced antitumor activity in melanoma murine cancer cells
Microencapsulated Brazil nut (Bertholletia excelsa) cake extract powder as an added-value functional food ingredient
Evaluation of the Comparability of Commercial Ghrelin Assays
This objective was to compare the two most commonly used commercial h-GHS RIAs, focusing on side-by-side determinations, recoveries, and assay imprecision, and to evaluate the suitability of the assays for determining intraindividual changes.
Comprehensive analysis by liquid chromatography Q-Orbitrap mass spectrometry: Fast screening of peptides and organic molecules.
- V. Sardela, M. E. Martucci, F. R. A. Aquino Neto
- ChemistryJournal of mass spectrometry : JMS
- 1 June 2018
A new analytical method was developed and validated for the simultaneous analysis of peptides and organic molecules using a single sample preparation and LC-Q-HRMS detection, and only FULL-MS/MS2 enables the detection of steroids and peptides at concentrations lower than the minimum required performance levels set by World Anti-Doping Agency.
Zebrafish (Danio rerio): A valuable tool for predicting the metabolism of xenobiotics in humans?
Stimulant Doping Agents Used in Brazil: Prevalence, Detectability, Analytical Implications, and Challenges
The high prevalence of stimulant doping in Brazil can be attributed to several reasons, including “self-administration,” a “body-shaping” culture, and the use of nutritional supplements.
Is zebrafish (Danio rerio) a tool for human-like metabolism study?
- C. de Souza Anselmo, V. Sardela, F. R. de Aquino Neto
- BiologyDrug testing and analysis
- 1 November 2017
It is demonstrated that adult zebrafish can absorb, oxidise, and excrete several metabolites in a manner similar to humans, which seems to be a very promising tool to study human-like metabolism when aiming to find analytical targets for doping control.
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry.
Pharmacokinetic study of xylazine in a zebrafish water tank, a human-like surrogate, by liquid chromatography Q-Orbitrap mass spectrometry
- Rebecca Rodrigues Matos, M. E. Martucci, Carina Souza de Anselmo, Francisco Radler Alquino Neto, H. Pereira, V. Sardela
- Chemistry, BiologyForensic Toxicology
- 31 July 2019
Xylazine was the subject of extensive metabolism in zebrafish and 4-Hydroxylated and oxygenated derivatives were the most abundant phase I metabolites as the main targets for doping control.
Comprehensive Zebrafish Water Tank Experiment for Metabolic Studies of Testolactone.
The data suggest that, while the concentration of testolactone was high enough to inhibit the aromatase enzyme, an accumulation of androgens in the water occurred, indicating that the ZWT can be considered a model to investigate the impact of steroids on live organisms.