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CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors
Macrophage phagocytosis of tumor cells mediated by CD47-specific blocking antibodies has been proposed to be the major effector mechanism in xenograft models. Here, using syngeneic immunocompetentExpand
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Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency
Reversible methylation of histone tails serves as either a positive signal recognized by transcriptional assemblies or a negative signal that result in repression. Invading viral pathogens thatExpand
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Resveratrol modulates autophagy and NF-κB activity in a murine model for treating non-alcoholic fatty liver disease.
In this study, we aimed to investigate the therapeutic effects and involved mechanisms of resveratrol on an established non-alcoholic fatty liver disease (NAFLD) murine model. Wild-type andExpand
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PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression
Programmed death–ligand 1 (PD-L1) expression on tumor cells is essential for T cell impairment, and PD-L1 blockade therapy has shown unprecedented durable responses in several clinical studies.Expand
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Identification of a Circulating MicroRNA Signature for Colorectal Cancer Detection
Prognosis of patients with colorectal cancer (CRC) is generally poor because of the lack of simple, convenient, and noninvasive tools for CRC detection at the early stage. The discovery of microRNAsExpand
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Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development
We aim to investigate the preventive and therapeutic effects of ghrelin on a rat NAFLD model and possible underlying mechanism. Sprague–Dawley rats were fed with high-fat diet for 8 weeks to induceExpand
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Laboratory biology of a uniparental strain of Meteorus pulchricornis (Hymenoptera: Braconidae), an exotic larval parasite of the gypsy moth (Lepidoptera: Lymantriidae)
The ovipositional response of a uniparental Korean strain of the parasite Meteorus pulchricornis (Wesmael) offered first to third instars of the gypsy moth, Lymantria dispar (L.), indicated thatExpand
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Molecular Phylogeny of the Lactuca Alliance (Cichorieae Subtribe Lactucinae, Asteraceae) with Focus on Their Chinese Centre of Diversity Detects Potential Events of Reticulation and Chloroplast
The first comprehensive molecular phylogenetic reconstruction of the Cichorieae subtribe Lactucinae is provided. Sequences for two datasets, one of the nuclear rDNA ITS region, the other of fiveExpand
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Brain-Targeted (Pro)renin Receptor Knockdown Attenuates Angiotensin II–Dependent Hypertension
The (pro)renin receptor is a newly discovered member of the brain renin-angiotensin system. To investigate the role of brain (pro)renin receptor in hypertension, adeno-associated virus-mediatedExpand
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A circulating non-coding RNA panel as an early detection predictor of non-small cell lung cancer.
AIMS Early non-small cell lung cancer (NSCLC) diagnosis is generally poor due to the lack of convenient and noninvasive tools. MicroRNAs (miRNAs) and the long non-coding RNA metastasis-associatedExpand
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