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Relative biological effectiveness (RBE) values for proton beam therapy.
PURPOSE Clinical proton beam therapy has been based on the use of a generic relative biological effectiveness (RBE) of 1.0 or 1.1, since the available evidence has been interpreted as indicating thatExpand
Range uncertainties in proton therapy and the role of Monte Carlo simulations.
  • H. Paganetti
  • Physics, Medicine
  • Physics in medicine and biology
  • 7 June 2012
The main advantages of proton therapy are the reduced total energy deposited in the patient as compared to photon techniques and the finite range of the proton beam. The latter adds an additionalExpand
Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer.
  • H. Paganetti
  • Physics, Medicine
  • Physics in medicine and biology
  • 31 October 2014
Proton therapy treatments are based on a proton RBE (relative biological effectiveness) relative to high-energy photons of 1.1. The use of this generic, spatially invariant RBE within tumors andExpand
TOPAS: an innovative proton Monte Carlo platform for research and clinical applications.
TLDR
PURPOSE While Monte Carlo particle transport has proven useful in many areas (treatment head design, dose calculation, shielding design, and imaging studies) and has been particularly important for proton therapy (due to the conformal dose distributions and a finite beam range in the patient), the available general purpose Monte Carlo codes in proton Therapy have been overly complex for most clinical medical physicists. Expand
Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles.
  • H. Paganetti
  • Materials Science, Medicine
  • Physics in medicine and biology
  • 15 February 2002
The dose distribution delivered in charged particle therapy is due to both primary and secondary particles. The secondaries, originating from non-elastic nuclear interactions, are of interest forExpand
A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction.
It has been long known that patients treated with ionizing radiation carry a risk of developing a second cancer in their lifetimes. Factors contributing to the recently renewed concern about theExpand
Proton therapy physics
Proton Therapy: History and Rationale, Harald Paganetti Physics of Proton Interactions in Matter, Bernard Gottschalk Proton Accelerators, Marco Schippers Characteristics of Clinical Proton Beams,Expand
Secondary Carcinogenesis in Patients Treated with Radiation: A Review of Data on Radiation-Induced Cancers in Human, Non-human Primate, Canine and Rodent Subjects
Abstract Suit, H., Goldberg, S., Niemierko, A., Ancukiewicz, M., Hall, E., Goitein, M., Wong, W. and Paganetti, H. Secondary Carcinogenesis in Patients Treated with Radiation: A Review of Data onExpand
Clinical implementation of full Monte Carlo dose calculation in proton beam therapy.
TLDR
The goal of this work was to facilitate the clinical use of Monte Carlo proton dose calculation to support routine treatment planning and delivery. Expand
Proton vs carbon ion beams in the definitive radiation treatment of cancer patients.
BACKGROUND AND PURPOSE Relative to X-ray beams, proton [(1)H] and carbon ion [(12)C] beams provide superior distributions due primarily to their finite range. The principal differences are LET, lowExpand
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