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Excessive burden of lysosomal storage disorder gene variants in Parkinson’s disease
Mutations in the glucocerebrosidase gene (GBA), which cause Gaucher disease, are also potent risk factors for Parkinson's disease. We examined whether a genetic burden of variants in other lysosomalExpand
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A susceptibility gene for late‐onset idiopathic Parkinson's disease
Eight regions of the genome (PARK1‐8) have been implicated in autosomal dominant and autosomal recessive forms of early‐onset Parkinson's disease. These forms constitute a few of all cases. However,Expand
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Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype
To determine if neuregulin 1 (NRG1) is associated with schizophrenia in Asian populations, we investigated a Han Chinese population using both a family trio design and a case–control design. A totalExpand
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Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing
BackgroundWhole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson’s disease (PD). However, until now this approach has not been deployed to study largeExpand
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Atypical juvenile parkinsonism in a consanguineous SPG15 family
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LINGO1 and clinical characteristics of essential tremor