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The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum.
Disruption of the DNA mismatch repair system, characterized by microsatellite instability (MI), plays an important role in the course of human carcinogenesis. Repetitive sequences constitute targets… Expand
DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.
Bacterial DNA and related synthetic immunostimulatory oligodeoxyribonucleotides (ISS-ODN) stimulate innate immunity. However, the molecular recognition mechanism that initiates signaling in response… Expand
Heat inactivation of Ku autoantigen: possible role in hyperthermic radiosensitization.
Heat shock prior, during, or immediately after ionizing radiation synergistically increases cell killing, a phenomenon termed hyperthermic radiosensitization. Recently, we have shown a constitutive… Expand
Restoration of T cell-specific V(D)J recombination in DNA-PKcs(-/-) mice by ionizing radiation: The effects on survival, development, and tumorigenesis.
- X. Li, S. Shen, Sa A. Wang, H. Ouyang, G. Li
- Biology, Medicine
- Sheng wu hua xue yu sheng wu wu li xue bao Acta…
- 1 March 2002
DNA-dependent protein kinase (DNA-PK) is a DNA-activated nuclear serine/threonine protein kinase. DNA-PK consists of a heterodimeric Ku subunit (composed of a 70 and 86 kD subunit) which binds DNA… Expand
RETRACTED: DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA
This article has been retracted at the request of the authors. Please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Reason: After publication of the… Expand
Suppression of heat-induced hsp 7 O expression by the 70-kDa subunit of the human Ku autoantigen ( gene regulation / heat shock protein / transcription factor / stable expression )
subunits . expression by Ku autoantigen or its individual Modulation of thermal induction of hsp 70
Disruption of NBS1 gene leads to early embryonic lethality in homozygous null mice and induces specific cancer in heterozygous mice
Nijmegen breakage syndrome (NBS) is a rare autosomal recessive chromosome instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition, with… Expand