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Rac1 is required for the formation of three germ layers during gastrulation
The Rac1, a member of the Rho family proteins, regulates actin organization of cytoskeleton and cell adhesion. We used genetic analysis to elucidate the role of Rac1 in mouse embryonic development.Expand
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K-Ras is essential for the development of the mouse embryo
ras genes encode members of the small GTP-binding proteins. Ras protein is highly conserved in various species from yeast to humans and plays a key role in signal transduction. Ras is related to cellExpand
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A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment
Nuclear protein kinases are believed to play important roles in regulating gene expression. We report here the identification and developmental expression of Dmnk (Drosophila maternal nuclearExpand
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Occlusion and subsequent re-canalization in early duodenal development of human embryos: integrated organogenesis and histogenesis through a possible epithelial-mesenchymal interaction
Histogenesis of the duodenum, especially changes in the epithelium in relation to temporal occlusion and re-canalization of the lumen, was investigated by light microscopy together with morphometricExpand
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Development of mitochondrial helical sheath in the middle piece of the mouse spermatid tail: Regular dispositions and synchronized changes
Morphologic changes in the development of the mitochondrial helical sheath in the mouse spermatid tail were examined with the scanning electron microscope (SEM) using the osmium‐DMSO‐osmium methodExpand
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Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus
Nature 372, 677-679(1994) THE panels of Fig. 2b of this Letter should have been labelled: left, FITC; middle, 12/101; right, FITC/TR.
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Ror2 is required for midgut elongation during mouse development
The receptor tyrosine kinase Ror2 acts as a receptor for Wnt5a to mediate noncanonical Wnt signaling, and it plays essential roles in morphogenesis. Ror2−/− embryos exhibit phenotypes similar to,Expand
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Apoptosis during inner ear development in human and mouse embryos: an analysis by computer-assisted three-dimensional reconstruction
 Apoptosis in the developing inner ear tissue of human (Carnegie stage 14 to 21, approximately 5 to 8 weeks of gestation) and mouse (10.5 to 14 days of gestation) embryos was systematically analyzedExpand
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Role of Wnt5a-Ror2 Signaling in Morphogenesis of the Metanephric Mesenchyme during Ureteric Budding
ABSTRACT Development of the metanephric kidney begins with the induction of a single ureteric bud (UB) on the caudal Wolffian duct (WD) in response to GDNF (glial cell line-derived neurotrophicExpand
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The role of leptin in the development of the cerebral cortex in mouse embryos.
Leptin is detected in the sera, and leptin receptors are expressed in the cerebrum of mouse embryos, suggesting that leptin plays a role in cerebral development. Compared with the wild type,Expand
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