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The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock.
In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks found throughout the body coordinate circadian rhythms of behavior and physiology. We characterize the clock ofExpand
Transcriptional Profiling in the Adrenal Gland Reveals Circadian Regulation of Hormone Biosynthesis Genes and Nucleosome Assembly Genes
The authors perform whole genome microarray hybridization to characterize the circadian transcriptome of the murine adrenal and identify classes of transcripts that may synchronize adrenal hormone production, suggesting a novel way by which the circadian clock may regulate the chromatin state. Expand
The acute light-induction of sleep is mediated by OPN4-based photoreception
It is found that the direct photic regulation of sleep in mice is predominantly mediated by melanopsin (OPN4)-based photoreception of photosensitive retinal ganglion cells (pRGCs), which is identified as a potentially new pharmacological target for the selective manipulation of sleep and arousal states. Expand
Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag.
The molecular response of the mouse circadian system in an established experimental paradigm for jet lag is characterized whereby mice entrained to a 12-hour light/12-hour dark cycle undergo light phase advancement by 6 hours, and strong heterogeneity of entrainment kinetics was found not only between different organs, but also within the molecular clockwork of each tissue. Expand
Circadian Regulation of Lipid Mobilization in White Adipose Tissues
Circadian modulation of lipolysis rates regulates the availability of lipid-derived energy during the day, suggesting a role for WAT clocks in the regulation of energy homeostasis. Expand
A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions
This paper introduces scientists to chronobiology by explaining the basic terminology used within the field and aims to assist in designing, carrying out, and evaluating wheel-running experiments with rodents, particularly mice. Expand
Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork
It is suggested that peripheral circadian desynchrony marks an early event in the metabolic disruption associated with chronic shiftwork, and strengthening the peripheral circadian system by minimizing food intake during night shifts may counteract the adverse physiological consequences frequently observed in human shift workers. Expand
Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses
It is demonstrated that lymphocyte trafficking through lymph nodes and lymph occurs in a circadian manner and that adaptive immune responses are also time‐of‐day dependent and are ablated when circadian clock function is lost in T cells. Expand
Disturbed Clockwork Resetting in Sharp-1 and Sharp-2 Single and Double Mutant Mice
The differential effects of Sharp-deficiency on rhythmicity and behavioral re-entrainment, coupled to tissue-dependent regulatory functions, provide a new mechanistic basis to further understand the complex process of clock synchronizations. Expand
Loss of circadian clock gene expression is associated with tumor progression in breast cancer
Co Coordinated co-expression of clock genes, indicative of a functional circadian clock, is maintained in ER+, HER2-, low grade and non-metastasizing tumors but is compromised in more aggressive carcinomas. Expand