H. Osiewacz

Publications211
h-index46
Citations9,435
Highly Influential Citations206
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Macromolecular organization of ATP synthase and complex I in whole mitochondria
TLDR
It is proposed that the supramolecular organization of respiratory chain complexes as proton sources and ATP synthase rows as propton sinks in the mitochondrial cristae ensures optimal conditions for efficient ATP synthesis.
Mitochondrial quality control: an integrated network of pathways.
TLDR
The elucidation of this network holds the key to the understanding of complex biological processes such as aging and the development of age-related diseases.
Differential expression of the psbA genes in the cyanobacterium Synechocystis 6803
TLDR
It is shown that the strikingly higher stability of the psbA transcripts in darkness compared to light, and the accumulation of a specific decay intermediate under dark conditions was reported previously, applies to both the PsbA-2 and psb a-3 transcripts.
Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models
TLDR
It is demonstrated that the dynamin-related protein 1 (Dnm1p), a mitochondrial fission protein conserved from yeast to humans, affects ageing in the two model systems the authors studied, Podospora anserina and Saccharomyces cerevisiae and links mitochondrial dynamics, apoptosis and life-span control.
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors
TLDR
A first characterization of CLPP null mice demonstrated complete female and male infertility and auditory deficits and showed resistance to ulcerative dermatitis, indicating that murine Clpp deletion represents a faithful Perrault model.
Copper homeostasis and aging in the fungal model system Podospora anserina: differential expression of PaCtr3 encoding a copper transporter.
TLDR
PaCtr3 is not expressed in the grisea mutant confirming the assumption that the extension of lifespan is primarily caused by cellular copper limitation and a switch from a cytochrome oxidase (COX)-dependent to and alternative oxidase-dependent respiration, and a strong link between copper-uptake, respiration and lifespan.
De novo Assembly of a 40 Mb Eukaryotic Genome from Short Sequence Reads: Sordaria macrospora, a Model Organism for Fungal Morphogenesis
TLDR
This study shows that, for typical filamentous fungi, de novo assembly of genomes from short sequence reads alone is feasible, that a mixture of Solexa and 454 sequencing substantially improves the assembly, and that the resulting data can be used for comparative studies to address basic questions of fungal biology.
Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageing model Podospora anserina
TLDR
The presented data strongly suggest that death of senescent wild‐type cultures is triggered by an apoptotic programme induced by an age‐dependent increase of reactive oxygen species during ageing of cultures and is executed after metacaspase activation.
Construction of an Obligate Photoheterotrophic Mutant of the Cyanobacterium Synechocystis 6803 : Inactivation of the psbA Gene Family.
TLDR
Results indicate that assembly of a partial Photosystem II complex may occur even in the absence of the intrinsic D1 polypeptide, a protein implicated as a crucial component of the photosystem II reaction center.
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