H. Osiewacz

Publications193
h-index41
Citations8,345
Highly Influential Citations212
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the… Expand
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Macromolecular organization of ATP synthase and complex I in whole mitochondria
We used electron cryotomography to study the molecular arrangement of large respiratory chain complexes in mitochondria from bovine heart, potato, and three types of fungi. Long rows of ATP synthase… Expand
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Mitochondrial quality control: an integrated network of pathways.
Mitochondria are organelles of eukaryotic cells with various functions. Best known is their role in energy transduction leading to the formation of ATP. As byproducts of this process, reactive oxygen… Expand
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Differential expression of the psbA genes in the cyanobacterium Synechocystis 6803
The 5′ region and transcription initiation sites of the psbA-2 and psbA-3 genes of Synechocystis 6803 were determined. The otherwise highly homologous genes were shown to diverge significantly in the… Expand
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Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors
Abstract The caseinolytic peptidase P (CLPP) is conserved from bacteria to humans. In the mitochondrial matrix, it multimerizes and forms a macromolecular proteasome-like cylinder together with the… Expand
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Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models
Ageing of biological systems is accompanied by alterations in mitochondrial morphology, including a transformation from networks and filaments to punctuate units. The significance of these… Expand
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Copper homeostasis and aging in the fungal model system Podospora anserina: differential expression of PaCtr3 encoding a copper transporter.
Lifespan extension of Podospora anserina mutant grisea is caused by a loss-of-function mutation in the nuclear gene Grisea. This gene encodes the copper regulated transcription factor GRISEA recently… Expand
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De novo Assembly of a 40 Mb Eukaryotic Genome from Short Sequence Reads: Sordaria macrospora, a Model Organism for Fungal Morphogenesis
Filamentous fungi are of great importance in ecology, agriculture, medicine, and biotechnology. Thus, it is not surprising that genomes for more than 100 filamentous fungi have been sequenced, most… Expand
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Guidelines and recommendations on yeast cell death nomenclature
Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cellular… Expand
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Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageing model Podospora anserina
Podospora anserina is a filamentous fungus with a limited lifespan. After a strain‐specific period of growth, cultures turn to senescence and ultimately die. Here we provide evidence that the last… Expand
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