• Publications
  • Influence
Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human Cells*
TLDR
It is concluded that NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress and further implies a novel application of the vitamin to treat diseases such as those associated with the depletion of cellular NAD pools. Expand
The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry.
TLDR
Using a liquid chromatographic-tandem mass spectrometric method, the amounts of NMN, NAMN, NAD(+), and 5'AMP present in mouse erythrocytes are measured, in a single analysis, and this is the first report of a direct determination of the amounts in any type of cell. Expand
Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma
TLDR
It is concluded that visfatin does not participate in NMN formation under the extracellular milieus, and the concept of NAMPT-mediated systemic NAD biosynthesis is not supported. Expand
Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells.
TLDR
This study indicates that the synergistic augmentation of the cytotoxicity by LY294002 occurs specifically with antimicrotubule agents, at least partially through an increase in caspase 3-dependent apoptosis, and suggests that inhibitors of the PI3K/Akt pathway in combination with antim Microtubule Agents may induce cell death effectively and be a potent modality to treat patients with malignant gliomas. Expand
Molecular Identification of Human Glutamine- and Ammonia-dependent NAD Synthetases
TLDR
The results indicate that the carbon-nitrogen hydrolase domain is the functional domain of NAD synthetase to make use of glutamine as an amide donor in NAD synthesis, and glutamine-dependent NAD Synthetase may be classified as a possible glutamine amidase in the nitrilase family. Expand
Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy. Laboratory investigation.
TLDR
Investigation of the possibility of IDO-dependent Trp depletion by malignant gliomas and the practicability of using an IDO inhibitor together with anticancer drugs to reserve Trp without decreasing the cytotoxicity of the drugs suggest that the robust IDO expression with rapid consumption of Trp in human glioma cells induced by IFN-gamma could lead to immune resistance in gli cancer cells. Expand
Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor.
TLDR
The findings show that PI3-K is a possible target for therapy in patients with gliomas, and PI3/Akt inhibitors in combination with chemotherapeutic agents could be potent therapeutic modalities for patients with malignant glioma. Expand
Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase.
TLDR
Arginine-ADP-ribosylated proteins in mouse spleen lymphocytes were identified using this method using the specific hydrolysis of ADp-ribose-arginine bond by GST-ADp- ribosyl arginine hydrolase. Expand
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with
TLDR
It is shown that Nampt is inhibited in cells and that enhanced expression of Nampt activates NAD+ breakdown, and the tight link between the NAD+ synthesis and its breakdown is shown. Expand
Cloning and expression of cDNA for arginine-specific ADP-ribosyltransferase from chicken bone marrow cells.
TLDR
Highly conserved regions were observed among the deduced amino acid sequences of AT1, AT2, rabbit skeletal muscle transferase, and rodent T-cell surface antigen RT6s. Expand
...
1
2
3
4
...