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A novel highly stereoselective synthesis of 2,3-disubstituted 3H-quinazoline-4-one derivatives.
[structure: see text]. An efficient three-step synthesis of chiral 3H-quinazoline-4-one derivatives from commercial materials is disclosed. The Mumm reaction of imidoyl chloride with alpha-aminoExpand
  • 42
Pyrolytic Generation and Rearrangement of N‐Substituted 1,2‐Didehydrocarbazoles
The flash vacuum pyrolysis (900–940°C) of a series of N-R-substituted carbazole-1,2-dicarboxylic anhydrides (R = methyl, phenyl, o-tolyl, benzyl, and ethyl) leads to 1,2-didehydrocarbazoles whichExpand
  • 7
A Convenient Synthesis of N,N′-dibenzyl-2,4-diaminopyrimidine-2′-deoxyribonucleoside and 1-Methyl-2′-Deoxypseudoisocytidine
The syntheses of N,N′-dibenzyl-2,4-diaminopyrimidine-2′-deoxyribonucleoside and 1-methyl-2′-deoxypseudoisocytidine via Heck coupling are described. A survey of the attempts to use the Heck couplingExpand
  • 7
Synthesis of the First Sialic Acid Analogue Containing a y-Pyrone Moiety
Oxidation of the two DANA (2-deoxy-2,3-didehydro-N-acetylneuraminic acid) derivatives (3) and (4) by using several reagents has led to the isolation of the first sialic acid derivative (1) containingExpand
  • 7
Heteroaryl derivatives useful to inhibit chk1 urea.
Compound which is 1- [5-bromo-4-methyl-2-S- (morpholin-2-ylmethoxy) -phenyl] -3- (5-methyl-pyrazin-2-yl) -urea or a pharmaceutically acceptable salt of the same.
Quinazolinone used as an inhibitor of phosphatidylinositol 3-kinase delta human
A pharmaceutically acceptable salt of the compound: ** ** Formula wherein the pharmaceutically acceptable salt is selected from the group consisting of hydrochloride, hydrobromide, hydroiodide andExpand
Heteroarylharnstoffderivate for inhibition of chk1
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