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Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats.
BACKGROUND AND PURPOSE It has been suggested that interleukin-1 (IL-1) is a potent inflammatory mediator and that it is synthesized and secreted into the brain parenchyma. The aim of the presentExpand
Correlation Between Myeloperoxidase‐Quantified Neutrophil Accumulation and Ischemic Brain Injury in the Rat: Effects of Neutrophil Depletion
Background and Purpose Neutrophils have been implicated in the pathogenesis of ischemia‐reperfusion injury. The aim of the present study was to evaluate the correlation between neutrophilExpand
Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy
8-hydroxy-2'-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG), a product of oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we measured the 8-OHdG/8-OHG levelsExpand
Carcinogenicity studies of sodium nitrite and sodium nitrate in F-344 rats.
The carcinogenicity of sodium and of sodium nitrate was examined in F-344 rats. Sodium nitrite was administered in the drinking-water for 2 yr at levels of 0.125 or 0.25%. Sodium nitrate was given inExpand
Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling
The expression of chemokine receptors on lymphocytes in the blood and CSF of multiple sclerosis (MS) patients was analyzed at relapse and remission. Both CD4+ and CD8+ cells in CSF at relapse wereExpand
Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat
Activated neutrophils appear to be directly involved in tissue injury after focal cerebral ischemia and reperfusion. Intercellular adhesion molecules-1 (ICAM-1) and CD11/CD18 integrins have beenExpand
Cyclosporin A protects against ischemia-reperfusion injury in the brain
We investigated the protective effect of Cyclosporin A (CsA) against ischemia-reperfusion injury in the brain using a transient focal ischemia model in rats. In CsA-treated rats, ischemic brain edemaExpand
New therapeutic possibility of blocking cytokine-induced neutrophil chemoattractant on transient ischemic brain damage in rats
Earlier we indicated that neutrophilic invasion into cerebral parenchyma is an important step in rat cerebral ischemia-reperfusion injury and the production of chemotactic factors, cytokine-inducedExpand
Mononucleotide Metabolism in the Rat Brain After Transient Ischemia
Nucleotide metabolism was studied in rats during and following the induction of 10 min of forebrain ischemia (four‐vessel occlusion model). Purine and pyrimidine nucleotides, nucleosides, and basesExpand
Relationship between the development of hepato-renal toxicity and cadmium accumulation in rats given minimum to large amounts of cadmium chloride in the long-term: preliminary study
Abstract We wished to clarify the relationship between the sensitivity to induce hepato-renal toxicity and the level of cadmium (Cd) in the organs of rats exposed to minimum to large amounts ofExpand