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CD36 Mediates the Cardiovascular Action of Growth Hormone-Releasing Peptides in the Heart
The coronary vasoconstrictive response correlated with expression of CD36 as assessed by immunoblotting and covalent binding with hexarelin suggest that CD36 may mediate the coronary vasospasm seen in hypercholesterolemia and atherosclerosis. Expand
Identification and characterization of a new growth hormone-releasing peptide receptor in the heart.
The results suggest the existence of a new class of hexarelin receptor in the heart, whose role in the regulation of the coronary vascular tone is yet to be determined. Expand
Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland.
The present data demonstrate that sGHS have specific receptors in human brain and pituitary gland and reinforce the hypothesis that these compounds could be the synthetic counterpart of an endogenous GH secretagogue involved in the neuroendocrine control of GH secretion and possibly in other central activities. Expand
Stoichiometry of the atrial natriuretic factor-R1 receptor complex in the bovine zona glomerulosa.
- J. Rondeau, N. McNicoll, J. Gagnon, N. Bouchard, H. Ong, A. De Léan
- Chemistry, Medicine
- 21 February 1995
Comparison of the measured number of ANF binding sites with immunoassayable receptor protein revealed that the stoichiometric ratio of the ANF-receptor complex was 1:2, and this was confirmed by using an ANF analog that bears a photoactivatable group at both of its ends, showing that ANF interacts with both the receptor subunits and specifically cross-links a dimeric form of the receptor. Expand
Allosteric modulation by ATP of the bovine adrenal natriuretic factor R1 receptor functions.
The results confirm the direct modulatory role of ATP on hormone binding activity of ANF-R1 receptor and suggest that the nucleotide regulatory binding site is located in the intracellular domain vicinal to the protease-sensitive region. Expand
Pituitary adenylate-cyclase activating polypeptide (PACAP) evokes long-lasting secretion and de novo biosynthesis of bovine adrenal medullary neuropeptides
It is concluded that PACAP might assume important noncholinergic trans-synaptic regulation of the adrenal medulla by releasing and modifying intragranular catecholamine and neuropeptide contents. Expand
Distinct properties of atrial natriuretic factor receptor subpopulations in epithelial and fibroblast cell lines.
- J. Féthière, S. Meloche, T. Nguyen, H. Ong, A. De Léan
- Biology, Medicine
- Molecular pharmacology
- 1 May 1989
Two atrial natriuretic factor (ANF) receptor subtypes are characterized in two established cell lines that express exclusively one receptor subtype and show the same structure and pharmacological characteristics as in the two model cell lines. Expand
Radioimmunoassay of atrial natriuretic factor: human plasma levels.
- P. Larose, S. Meloche, P. du Souich, A. Deléan, H. Ong
- Chemistry, Medicine
- Biochemical and biophysical research…
- 31 July 1985
A simple and sensitive radioimmunoassay procedure has been developed for the determination of atrial natriuretic factor (ANF) in human plasma and showed the presence of one immunoreactive peak of ANF corresponding to its low molecular weight form. Expand
Functional heterogeneity of atrial natriuretic factor receptor in bovine adrenal zona glomerulosa is explained by an amiloride-sensitive high affinity molecular complex.
The effects of amiloride on the molecular characteristics of the atrial natriuretic factor (ANF) receptor from bovine adrenal zona glomerulosa were studied by computer modeling of competitive binding… Expand
Identification of a pituitary growth hormone-releasing peptide (GHRP) receptor subtype by photoaffinity labeling.
This photoactivatable Hexarelin derivative has allowed the identification of a pituitary GHRP receptor subtype, which is apparently distinct from the recently cloned GH secretagogue receptor. Expand