• Publications
  • Influence
N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis
TLDR
NDRG1 is identified as a novel negative master regulator of Wnt signalling during the metastatic progression, which opens an opportunity to define a potential therapeutic target for metastatic disease.
Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
BMP7 released by bone marrow stromal cells induces reversible senescence of prostate cancer stem-like cells, and BMPR2 expression inversely correlates with bone metastasis and recurrence in prostate
miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4.
TLDR
It is found that CSCs isolated from metastatic breast cell lines are significantly more metastatic than non-CSC populations in an organ-specific manner and in vitro experiments indicate that miR-7 attenuates the abilities of invasion and self-renewal of C SCs by modulating KLF4 expression.
Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells
Notch signaling is often and aberrantly activated by hypoxia during tumor progression; however, the exact pathological role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly
Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain
TLDR
The results represent a novel paradigm for the understanding of how metastatic breast CSCs re‐establish their niche for their self‐renewal in a totally different microenvironment, which opens a new avenue to identify a novel and specific target for the brain metastatic disease.
RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer.
TLDR
The results indicate that RhoC promotes tumor metastasis in prostate cancer by sequential activation of Pyk2, FAK, MAPK, and Akt followed by the up-regulation of MMP2 and MMP9, which results in the stimulation of invasiveness of tumor cells.
Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
TLDR
The results of this study indicate that resveratrol is capable of inducing apoptosis in the cancer stem-like cells through suppression of lipogenesis by modulating FAS expression, which highlights a novel mechanism of anti-tumor effect of resver atrol.
WNT7A Regulates Tumor Growth and Progression in Ovarian Cancer through the WNT/β-Catenin Pathway
TLDR
It is suggested that reexpression of WNT7A during malignant transformation of ovarian epithelial cells plays a critical role in ovarian cancer progression mediated by WNT/β-catenin signaling pathway.
Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells.
TLDR
The findings show a critical role of HAS2 in the development of a prometastatic microenvironment and suggest that HAS2 inhibitors can act as antimetastsatic agents that disrupt a paracrine growth factor loop within this microenvironment.
...
...