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Novel antitumor indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11- dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4- c]carbazole-5,7(6H)-dione (NB-506): induction of…
TLDR
NB-506 is a potent topoisomerase I poison, acting selectively on tumor cell lines accumulating NB-506, and its cytotoxicity was found to be cell line selective.
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BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties.
TLDR
The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells, but showed cytotoxic activity against mammalian cells such as P388 mouse leukemia.
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Biological properties of streptonigrin derivatives. II. Inhibition of reverse transcriptase activity.
TLDR
Antitumor antibiotic streptonigrin (STN-COOH) is a potent inhibitor of avian myeloblastosis virus (AMV) and human immunodeficiency virus reverse transcriptases and doxorubicin-resistant murine lymphoblastoma L5178Y cells showed collateral sensitivity to both STN- COOH and STN (CH2)3N(CH3)2 not only in vitro but also in vivo.
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Biological properties of streptonigrin derivatives. I. Antimicrobial and cytocidal activities.
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A new topoisomerase II inhibitor, BE-22179, produced by a streptomycete. I. Producing strain, fermentation, isolation and biological activity.
A new topoisomerase II inhibitor, designated BE-22179, was isolated from the culture broth of Streptomyces sp. A22179, which resembles "Streptomyces gangtokensis". The inhibitor was extracted from…
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A new group of antibiotics, hydroxamic acid antimycotic antibiotics. II. The structure of neoenactins NL1 and NL2 and structure-activity relationship.
The structures of neoenactins (NEs) NL1 and NL2, novel antimycotic antibiotics produced by Streptoverticillium olivoreticuli in a precursor-oriented fashion, were elucidated by 1H and 13C NMR and…
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BE-29602, a new member of the Papulacandin family.
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Inhibition of Topoisomerase II by a Novel Antitumor Cyclic Depsipeptide, BE‐22179
TLDR
BE‐22179, a novel cyclic depsipeptide antibiotic having two 3‐hydroxyquinoline moieties, inhibited the DNA‐relaxing activity of L1210 topoisomerase II completely at 0.08 μM and showed DNA‐intercalating ability (DNA unwinding) at 30 μM, while Echinomycin, a quinoxaline antibiotic structurally related to BE, interfered with DNA relaxation by topoisomersase II.
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Effects of streptonigrin derivatives and sakyomicin A on the respiration of isolated rat liver mitochondria.
Though all the streptonigrin derivatives with modifications in the carboxyl group on C2' were active as electron acceptors in the oxidation of NADH by Clostridium kluyveri diaphorase as well as…
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Hydroxamic Acid Antimycotic Antibiotics
TLDR
Enactins, and neoenactins' are antimycotic antibiotics discovered by this screening method as potentiaters of polyene antifungal antibiotics as well as several congeners containing L-serine.
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