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Complete Relative Stereochemistry of Maitotoxin
By addressing the relative stereochemistry of the four acyclic portions via organic synthesis, the complete relative stereochemistry of maitotoxin (MTX) has been established as 1B. The relative…
Synthesis and biological evaluation of substituted benzenesulfonamides as novel potent membrane-bound phospholipase A2 inhibitors.
A novel series of 4-[N-methyl-N-[(E)-3-[4-(methylsulfonyl)phenyl]-2- propenoyl]amino]benzenesulfonamides has been prepared and evaluated as membrane-bound phospholipase A2 inhibitors and the optimum potency was realized with the N-(phenylalkyl)piperidine derivatives 3 and 4.
The Stereochemical Assignment and Conformational Analysis of the V/W- Ring Juncture of Maitotoxin
The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold.
The Stereochemical Assignment and Conformational Analysis of the V/W-Ring Juncture of Maitotoxin
The unambiguous stereochemical assignment of the V/W-ring juncture of maitotoxin, as shown in Figure 1, was accomplished using a two-step approach: (1) the synthesis of two diastereomeric models…
4'-[(4-Piperidyl)carbonyl]methanesulfonanilides as potent, selective, bioavailable class III antiarrhythmic agents.
A stereoselective synthesis of α-isosparteine
Successive cycloaddition of Δ1-piperidiene 1-oxide to 4H-pyran proceeded regio- and stereo-selectively to afford a 2:1 adduct, catalytic hydrogenation of which gave α-isosparteine in high yield.
Stereoselective syntheses of α-isosparteine
Stereoselective syntheses of α-isosparteine were accomplished by means of 1,3-dipolar cycloadditions. The cycloaddition of nitrone (4) to cyclopentadiene proceeded stereoselectively to afford…
Stereoselective Syntheses of α-Isosparteine.
Piperidine derivatives and pharmaceutical preparations containing these