H. Ohta

Publications290
h-index47
Citations9,542
Highly Influential Citations774
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Lagrangian intersection floer theory : anomaly and obstruction
Part I Introduction Review: Floer cohomology The $A_\infty$ algebra associated to a Lagrangian submanifold Homotopy equivalence of $A_\infty$ algebras Homotopy equivalence of $A_\infty$ bimodules… Expand
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Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells
The generation of properly functioning gametes in vitro requires reconstitution of the multistepped pathway of germ cell development. We demonstrate here the generation of primordial germ cell-like… Expand
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Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer.
The low success rate of animal cloning by somatic cell nuclear transfer (SCNT) is believed to be associated with epigenetic errors including abnormal DNA hypermethylation. Recently, we elucidated by… Expand
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A Signaling Principle for the Specification of the Germ Cell Lineage in Mice
Specification of the germ cell lineage is vital to development and heredity. In mice, the germ cell fate is induced in pluripotent epiblast cells by signaling molecules, yet the underlying mechanism… Expand
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Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice
Artificially Induced Oocytes In mice, male embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been shown to differentiate into primordial germ cell–like cells (PGCLCs) in… Expand
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PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells.
In serum, mouse embryonic stem cells (mESCs) fluctuate between a naive inner cell mass (ICM)-like state and a primed epiblast-like state, but when cultured with inhibitors of the mitogen-activated… Expand
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Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
Mechanisms underlying human germ cell development are unclear, partly due to difficulties in studying human embryos and lack of suitable experimental systems. Here, we show that human induced… Expand
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Lagrangian Floer theory on compact toric manifolds, I
The present authors introduced the notion of \emph{weakly unobstructed} Lagrangian submanifolds and constructed their \emph{potential function} $\mathfrak{PO}$ purely in terms of $A$-model data in… Expand
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Induction of mouse germ-cell fate by transcription factors in vitro
The germ-cell lineage ensures the continuity of life through the generation of male and female gametes, which unite to form a totipotent zygote. We have previously demonstrated that, by using… Expand
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Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway
Stem cell regulatory mechanisms are difficult to study because self-renewal and production of differentiated progeny, which are both strictly controlled, occur simultaneously in these cells. To focus… Expand
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