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Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
TLDR
Using a rational approach to isolate CD4+FOXP3+ regulatory T (Treg)-cell-inducing bacterial strains from the human indigenous microbiota may allow for tailored therapeutic manipulation of human immune disorders.
View on Nature
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
TLDR
It is shown that a large bowel microbial fermentation product, butyrate, induces the differentiation of colonic Treg cells in mice and ameliorated the development of colitis induced by adoptive transfer of CD4+ CD45RBhi T cells in Rag1−/− mice.
View on Nature
Interaction of tyrosine-based sorting signals with clathrin-associated proteins.
TLDR
The medium chains of two clathrin-associated protein complexes specifically interacted with tyrosine-based signals of several integral membrane proteins, and it is likely that the medium chains serve as signal-binding components of the clathin-dependent sorting machinery.
View on PubMed
Bifidobacteria can protect from enteropathogenic infection through production of acetate
TLDR
It is proposed that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.
View on Nature
A promoter-level mammalian expression atlas
TLDR
It is found that few genes are truly ‘housekeeping’, whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles.
View on Nature
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
View on Elsevier
M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex
TLDR
It is reported that a mammalian protein, M-Sec, induces de novo formation of numerous membrane protrusions extending from the plasma membrane, some of which tether onto adjacent cells and subsequently form TNT-like structures.
View on Nature
A Novel Clathrin Adaptor Complex Mediates Basolateral Targeting in Polarized Epithelial Cells
View on Elsevier
Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response
TLDR
GP2 is a previously unrecognized transcytotic receptor on M cells for type-I-piliated bacteria and is a prerequisite for the mucosal immune response to these bacteria, which could provide a new target for the development of M-cell-targeted mucosal vaccines.
View on Nature
AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis
TLDR
The clathrin adaptor protein AP-1 and the motor KIF13A work together to deliver cargo into maturing melanosomes and form a ‘spatially aggregating force’ to propel the cell towards apoptosis.
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