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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induceExpand
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Bifidobacteria can protect from enteropathogenic infection through production of acetate
The human gut is colonized with a wide variety of microorganisms, including species, such as those belonging to the bacterial genus Bifidobacterium, that have beneficial effects on human physiologyExpand
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M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex
Cell–cell communication is essential for the development and homeostasis of multicellular organisms. Recently, a new type of cell–cell communication was discovered that is based on the formation ofExpand
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Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response
The mucosal immune system forms the largest part of the entire immune system, containing about three-quarters of all lymphocytes and producing grams of secretory IgA daily to protect the mucosalExpand
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A Novel Clathrin Adaptor Complex Mediates Basolateral Targeting in Polarized Epithelial Cells
Although polarized epithelial cells are well known to maintain distinct apical and basolateral plasma membrane domains, the mechanisms responsible for targeting membrane proteins to the apical orExpand
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Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
Intestinal Th17 cells are induced and accumulate in response to colonization with a subgroup of intestinal microbes such as segmented filamentous bacteria (SFB) and certain extracellular pathogens.Expand
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Identity of the elusive IgM Fc receptor (FcμR) in humans
Although Fc receptors (FcRs) for switched immunoglobulin (Ig) isotypes have been extensively characterized, FcR for IgM (FcμR) has defied identification. By retroviral expression and functionalExpand
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Comparative Genome Analysis of Lactobacillus reuteri and Lactobacillus fermentum Reveal a Genomic Island for Reuterin and Cobalamin Production
Lactobacillus reuteri is a heterofermentative lactic acid bacterium that naturally inhabits the gut of humans and other animals. The probiotic effects of L. reuteri have been proposed to be largelyExpand
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AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis
The clathrin adaptor protein AP-1 and the motor KIF13A work together to deliver cargo into maturing melanosomes.
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Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components
Targeting of transmembrane proteins to lysosomes, endosomal compartments, or the trans-Golgi network is largely dependent upon cytoplasmically exposed sorting signals. Among the most widely usedExpand
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