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Cyclophilin inhibitors reduce phosphorylation of RNA-dependent protein kinase to restore expression of IFN-stimulated genes in HCV-infected cells.
TLDR
It is found that cyclophilin inhibitors reduce phosphorylation of PKR and eIF2α during HCV infection to allow for translation of ISG products. Expand
Interleukin-1 and Tumor Necrosis Factor-α Trigger Restriction of Hepatitis B Virus Infection via a Cytidine Deaminase Activation-induced Cytidine Deaminase (AID)*
TLDR
It is found that pretreatment with IL-1β and TNFα remarkably reduced the host cell susceptibility to HBV infection, and this effect was mediated by activation of the NF-κB signaling pathway. Expand
A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide
TLDR
A fungal metabolite, vanitaracin A, is identified, which was a potent, well-tolerated, and broadly active inhibitor of HBV and HDV entry and could be part of an antiviral strategy for preventing reinfection with HBV, including clinically relevant nucleos(t)ide analog-resistant virus. Expand
Multidrug treatment with nelfinavir and cepharanthine against COVID-19
TLDR
This study identifies a new multidrug combination treatment for COVID-19 that combines the HIV protease inhibitor Nelfinavir and the anti-inflammatory drug Cepharanthine to limit SARS-CoV-2 proliferation. Expand
Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection
TLDR
This study showed how cell culture data can be combined with a mathematical model and computer simulation to quantify the anti-HCV drug efficacy of different drug concentrations and combinations in a preclinical setting, and hence develop a quantitative basis for selecting drug combinations prior to costly clinical trials. Expand
The aryl hydrocarbon receptor–cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly
TLDR
It is demonstrated that the benzamide derivative flutamide reduces the host capacity to produce infectious HCV and that the AhR–CYP1A1 pathway has a significant role in lipid accumulation, a hallmark of HCV infection that maximizes progeny virus production. Expand
A new strategy to identify hepatitis B virus entry inhibitors by AlphaScreen technology targeting the envelope-receptor interaction.
TLDR
This is the first report for application of AlphaScreen technology that monitors a viral envelope-receptor interaction to identify viral entry inhibitors, and rapamycin, an immunosuppressant, strongly inhibited the LHBs-NTCP interaction. Expand
Modelling SARS-CoV-2 Dynamics: Implications for Therapy
TLDR
It is indicated that therapies that block de novo infections or virus production are most likely to be effective if initiated before the peak viral load, but therapies that promote cytotoxicity are likely to have only limited effects. Expand
Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System
TLDR
The identification of neoechinulin B (NeoB) as a novel inhibitor of the liver X receptor (LXR) directly links the identification of novel bioactive compounds to basic virology and the development of new antiviral agents. Expand
The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network
TLDR
The results support the idea that the EGFR endocytosis/sorting machinery drives the translocation of NTCP-bound HBV from the cell surface to the endosomal network, which eventually enables productive viral infection. Expand
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