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TERRA RNA Antagonizes ATRX and Protects Telomeres
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A crucial role of WW45 in developing epithelial tissues in the mouse
TLDR
Data provided provide compelling evidence that WW45 is a key mediator of MST1 signalling in the coordinate coupling of proliferation arrest with terminal differentiation for proper epithelial tissue development in mammals.
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SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X
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Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.
TLDR
Findings indicate that RASSF1A facilitates Mst1 activation and thereby promotes apoptosis induced by death receptor signaling.
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The tumour suppressor RASSF1A promotes MDM2 self‐ubiquitination by disrupting the MDM2–DAXX–HAUSP complex
TLDR
This work shows that the tumour suppressor RASSF1A regulates G1–S cell‐cycle progression in a p53‐dependent manner by promoting MDM2 self‐ubiquitination and preventing p53 degradation, and reveals a new and important function for RASSf1A in regulating the p53–MDM2 pathway.
View on Wiley
Mst1-FoxO Signaling Protects Naïve T Lymphocytes from Cellular Oxidative Stress in Mice
TLDR
These data support the hypothesis that tolerance to increased levels of intracellular ROS provided by the Mst1-FoxOs signaling pathway is crucial for the maintenance of naïve T cell homeostasis in the periphery.
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Crucial Role for Mst1 and Mst2 Kinases in Early Embryonic Development of the Mouse
TLDR
Findings indicate that both Mst1 and Mst2 kinases play essential roles in early mouse development, regulating placental development, vascular patterning, primitive hematopoiesis, and cell proliferation and survival.
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Daxx mediates activation‐induced cell death in microglia by triggering MST1 signalling
TLDR
It is shown that Daxx and mammalian Ste20‐like kinase‐1 (MST1) mediate apoptosis elicited by interferon‐γ (IFN‐γ) in microglia and are the key mediators of microglial cell death initiated by the proinflammatory cytokine IFn‐γ.
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PAR-TERRA directs homologous sex chromosome pairing
TLDR
A required interaction between the X-inactivation center (Xic) and the telomere in mouse embryonic stem (ES) cells is revealed and a 'constrained diffusion model' in which PAR-TERRA creates an interaction hub to guide Xic homology searching during XCI is proposed.
View on Nature
MST1 Limits the Kinase Activity of Aurora B to Promote Stable Kinetochore-Microtubule Attachment
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