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The structures of novel nucleoside antibiotics, miharamycin A and miharamycin B
Abstract Based on 13 C- and 1 H-NMR spectral analysis the structures of miharamycins A and B have been determined to be novel 9-substituted 2-aminopurine nucleoside antibiotics as shown in Fig. 3.
Oligostatins, new antibiotics with amylase inhibitory activity, II. Structures of oligostatins C, D, and E.
TLDR
Oligostatins C, D and E are pseudo-penta, -hexa and -heptasaccharides with a nitrogen containing glycosidic bond and represent a new series of amylase inhibitors of the saturated basic oligosaccharide. Expand
Oligostatins, new antibiotics with amylase inhibitory activity. I. Production, isolation and characterization.
Oligostatins C, D and E, three new antibiotics were found in the culture filtrate of Streptomyces myxogenes nov. sp. SF-1130. Their spectral and chemical properties suggested that oligostatins wereExpand
New aminothiazolylglycylcephalosporins with a 1,5-dihydroxy-4-pyridone-2-carbonyl group. I. Synthesis and biological activity of cephalosporin derivatives leading to MT0703.
TLDR
A series of new aminothiazolylglycylcephalosporins with a mono- or dihydroxypyridonecarbonyl group at the alpha-amino group of the C-7 substituent showed excellent anti-pseudomonal activity and was found to be a well balanced compound with respect to antibacterial activity. Expand
New aminothiazolylglycylcephalosporins with a 1,5-dihydroxy-4-pyridone-2-carbonyl group. II. Synthesis and antibacterial activity of MT0703 and its diastereomers.
TLDR
The S- isomer of MT0703 was found to be more active against Gram-positive and Gram-negative bacteria including beta-lactamase-producing strains than the R-isomer. Expand
Synthesis and biological activity of 7 beta-(2-amino-2-carboxy)-ethylthioacetamido-7 alpha-methoxycephalosporin derivatives.
TLDR
Among a large number of derivatives, MT-141 possessing 2-D-2-amino- 2-carboxyethylthioacetamido residue at C-7 and N-methyltetrazolyl-thiomethyl residue atC-3 showed a high order of antibacterial activity in vitro and especially in vivo. Expand
A new antipseudomonal cephalosporin CP6162 and its congeners.
The synthesis and biological activity of a series of 3-[2-(5-hydroxy-4-pyridon-2-yl)ethenyl]cephalosporin derivatives are described. They showed very potent activity against Gram-negative bacteria,Expand
Modification of the macrolide antibiotic midecamycin. III. Formation of neoisomidecamycin.
TLDR
The formation of neoisomacrolides was dependent on the nature of protective groups and conditions of deprotective reaction, and treatment of 9-trichloroethoxycarbonylmidecamycin with Zn/acetic acid resulted in no allylic rearrangement. Expand
Studies on SF=1902 A2 A5, minor components of SF-1902 (globomycin).
TLDR
Four members of globomycin, SF-1902 A2, A3, A4a and A4b were newly isolated from the culture of Streptomyces hygroscopicus SF- 1902 and maximum activity was shown by the homologue (A5) possessing the longest alkyl chain. Expand
SF-1961, a new antibiotic related to bleomycin.
A new type of bleomycin group antibiotic, SF-1961 was isolated from the fermentation broth of Streptomyces species. SF-1961 possessed beta-amino-beta-(4-amino-6-carboxypyrimidin-2-yl)-propionic acidExpand
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