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The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
It is shown that a T-cell-specific, SLAM-associated protein (SAP), which contains an SH2 domain and a short tail, acts as an inhibitor by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region.
Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.
IgE Enhances Mouse Mast Cell FcεRI Expression In Vitro and In Vivo: Evidence for a Novel Amplification Mechanism in IgE-dependent Reactions
The demonstration that IgE-dependent enhancement of mast cell FcεRI expression permits mast cells to respond to antigen challenge with increased production of proinflammatory and immunoregulatory mediators provides new insights into both the pathogenesis of allergic diseases and the regulation of protective host responses to parasites.
A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis.
Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis.
- J. Spergel, E. Mizoguchi, H. Oettgen, A. Bhan, R. Geha
- Biology, MedicineThe Journal of clinical investigation
- 15 April 1999
Results suggest that both the TH2 cytokines IL-4 and IL-5 and the TH1 cytokine IFN-gamma play important roles in the inflammation and hypertrophy of the skin in AD.
Active anaphylaxis in IgE-deficient mice
- H. Oettgen, T. Martin, A. Wynshaw-Boris, C. Deng, J. Drazen, P. Leder
- Biology, MedicineNature
- 4 August 1994
It is reported that despite the IgE deficiency, sensitized mutant mice become anaphylactic on antigen challenge and display tachycardia and pulmonary function changes similar to those seen in wild-type animals, demonstrating that non-IgE pathways for hypersensi-tivity reactions exist in mice.
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
- V. Pivniouk, T. Martin, J. Lu-Kuo, H. Katz, H. Oettgen, R. Geha
- BiologyThe Journal of clinical investigation
- 15 June 1999
Results suggest that SLP-76 plays an important role in FcepsilonRI-mediated signaling in mast cells and Bone marrow-derived mast cells from SLP76(-/-) mice failed to release beta-hexosaminidase and to secrete IL-6 after FcePSilonRI cross-linking.
Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.
IgE Enhances Parasite Clearance and Regulates Mast Cell Responses in Mice Infected with Trichinella spiralis 1
It is concluded that IgE promotes parasite expulsion from the gut following T. spiralis infection and participates in the response to larval stages of the parasite.