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Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island
TLDR
The data suggest that normal repair of a DNA break can occasionally cause heritable silencing of a CpG island–containing promoter by recruitment of proteins involved in silencing.
Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation.
TLDR
A potential mechanism through assembly of novel repressive complexes, by which the polycomb component of PRC1 can promote the initiation of epigenetic changes involving abnormal DNA hypermethylation of genes frequently silenced in adult cancers is proposed.
RPA and ATR link transcriptional stress to p53
TLDR
It is proposed that this transcription-based stress response involving RPA, ATR, and p53 has evolved as aDNA damage-sensing mechanism to safeguard cells against DNA damage-induced mutagenesis.
Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress.
TLDR
The results suggest that the p53 proteins accumulating in the nucleus following UV-irradiation or blockage of transcription are freely soluble and, thus, should be able to roam the nucleus to ensure high occupancy of p53 binding sites.
The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer
TLDR
The roles inflammation and inflammatory mediators play in the development, progression, metastasis, and chemoresistance of EOC are discussed.
Frequent Inactivation of Cysteine Dioxygenase Type 1 Contributes to Survival of Breast Cancer Cells and Resistance to Anthracyclines
TLDR
The importance of CDO1 inactivation in breast cancer and its clinical potential as a biomarker and therapeutic target to overcome resistance to anthracyclines are shown.
Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation
TLDR
It is proposed that the elongating RNA polymerase complex may act as a sensor of DNA damage and as an integrator of cellular stress signals after blockage of transcription triggers a distinct signaling pathway leading to p53 modifications on ser15 and lys382.
Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer
TLDR
Findings suggest that DNA methylation-mediated silencing of the neurofilament genes NEFH, NEFM, and NEFL are frequent events that may contribute to the progression of breast cancer and possibly other malignancies.
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