Small-molecule agonists and antagonists of F-box protein–substrate interactions in auxin perception and signaling
- Ken-ichiro Hayashi, Xu Tan, H. Nozaki
- BiologyProceedings of the National Academy of Sciences
- 8 April 2008
The design, synthesis, and characterization of a series of auxin agonists and antagonists are described, which support the idea that it may be possible to design small-molecule agents to modulate ubiquitin-ligase function therapeutically and demonstrate an example of a specific small- molecule inhibitor of F-box protein–substrate recruitment.
Identification and functional analysis of bifunctional ent‐kaurene synthase from the moss Physcomitrella patens
- Ken-ichiro Hayashi, H. Kawaide, Miho Notomi, Yuka Sakigi, A. Matsuo, H. Nozaki
- ChemistryFEBS Letters
- 13 November 2006
Rational design of an auxin antagonist of the SCF(TIR1) auxin receptor complex.
- Ken-ichiro Hayashi, Joshua Neve, H. Nozaki
- ChemistryACS Chemical Biology
- 24 January 2012
A potent auxin antagonist is identified and a new class of small molecule inhibitor of protein-protein interactions common to mechanisms of perception of other plant hormones is demonstrated, such as jasmonate, gibberellin, and abscisic acid.
Yokonolide B, a Novel Inhibitor of Auxin Action, Blocks Degradation of AUX/IAA Factors*
- Ken-ichiro Hayashi, A. Jones, H. Nozaki
- BiologyJournal of Biological Chemistry
- 27 June 2003
Results indicate that YkB acts to block AUX/IAA protein degradation upstream of AXR and TIR, links a shared element upstream ofAUX/ IAA protein stability to auxin-induced cell division/elongation and to Auxin-binding protein 1, and provides a new tool to dissect auxin signal transduction.
Anion Distributions and Phase Transitions in CuS1-xSex(x = 0-1) Studied by Raman Spectroscopy
- M. Ishii, K. Shibata, H. Nozaki
- Chemistry
- 1 August 1993
Anion distributions and phase transitions in CuS1-xSex (x = 0-1), which are isostructural with CuS (covellite), have been studied through the Raman spectroscopic measurements. In hexagonal CuS type…
Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis.
- Xinhua Dai, Ken-ichiro Hayashi, H. Nozaki, Youfa Cheng, Yunde Zhao
- ChemistryProceedings of the National Academy of Sciences…
- 22 February 2005
It is shown that sirtinol and HNA could bypass the auxin polar transport system and that they were transported efficiently to aerial parts of seedlings, whereas HNC and 1-naphthoic acid were essentially not absorbed by Arabidopsis seedlings.
Arabidopsis Aux/IAA genes are involved in brassinosteroid-mediated growth responses in a manner dependent on organ type.
- A. Nakamura, N. Nakajima, S. Fujioka
- BiologyThe Plant Journal
- 2006
The results suggest that Aux/IAA proteins function in auxin- and BR-signaling pathways, and that IAA proteins function as the signaling components modulating BR sensitivity in a manner dependent on organ type.
Alkoxy-auxins Are Selective Inhibitors of Auxin Transport Mediated by PIN, ABCB, and AUX1 Transporters*
- Etsuko Tsuda, Haibing Yang, Ken-ichiro Hayashi
- Chemistry, Environmental ScienceJournal of Biological Chemistry
- 17 November 2010
It is indicated that alkoxy-auxins are inactive auxin analogs for auxin signaling, but are recognized by PIN, ABCB, and AUX1 auxin transport proteins, which are powerful new tools for analyses of auxin-dependent development.
Characterization of Terfestatin A, a New Specific Inhibitor for Auxin Signaling1[w]
- A. Yamazoe, Ken-ichiro Hayashi, S. Kepinski, O. Leyser, H. Nozaki
- Environmental SciencePlant Physiology
- 23 September 2005
Results indicate that TrfA acts as a modulator of Aux/IAA stability and thus provides a new tool for dissecting auxin signaling.
Pheophytin a, a low molecular weight compound found in the marine brown alga Sargassum fulvellum, promotes the differentiation of PC12 cells
- A. Ina, K. Hayashi, H. Nozaki, Y. Kamei
- BiologyInternational Journal of Developmental…
- 1 February 2007
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