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Effect of matrix elasticity on the maintenance of the chondrogenic phenotype.
The aim of this study was to examine the influence of matrix elasticity on the maintenance of the chondrogenic phenotype of chondrocytes cultured in monolayer. We used a two-dimensional culturingExpand
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High‐level production of human type I collagen in the yeast Pichia pastoris
Four human genes, two of them encoding the proα1 and proα2 chains of type I procollagen and two of them the two types of subunit of prolyl 4‐hydroxylase (4‐PH), were integrated into the genome ofExpand
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Characterization of Human Type III Collagen Expressed in a Baculovirus System
An efficient expression system for recombinant collagens would have numerous scientific and practical applications. Nevertheless, most recombinant systems are not suitable for this purpose, as theyExpand
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Jellyfish collagen scaffolds for cartilage tissue engineering.
Porous scaffolds were engineered from refibrillized collagen of the jellyfish Rhopilema esculentum for potential application in cartilage regeneration. The influence of collagen concentration,Expand
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Chondrocyte redifferentiation in 3D: the effect of adhesion site density and substrate elasticity.
To obtain sufficient cell numbers for cartilage tissue engineering with autologous chondrocytes, cells are typically expanded in monolayer culture. As a result, they lose their chondrogenic phenotypeExpand
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Collagen : primer in structure, processing and assembly
J. Brinckmann: Collagens at a Glance.- J. Engel, H.P. Bachinger: Structure, Stability and Folding of the Collagen Triple Helix.- S. Ricard-Blum, F. Ruggiero, M. van der Rest: The CollagenExpand
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The influence of matrix elasticity on chondrocyte behavior in 3D
Cells actively probe the stiffness of their surrounding and respond to it. The authors recently found that maintenance of the chondrogenic phenotype was directly influenced by this property in 2D.Expand
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Mutations in Calcium-binding Epidermal Growth Factor Modules Render Fibrillin-1 Susceptible to Proteolysis
Most extracellular proteins consist of various modules with distinct functions. Mutations in one common type, the calcium-binding epidermal growth factor-like module (cbEGF), can lead to a variety ofExpand
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Microfibrils at Basement Membrane Zones Interact with Perlecan via Fibrillin-1*
Mutational defects in fibrillin-rich microfibrils give rise to a number of heritable connective tissue disorders, generally termed microfibrillopathies. To understand the pathogenesis of theseExpand
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Molecular structure and interaction of recombinant human type XVI collagen.
Collagen XVI is a minor component of at least two different extracellular fibrillar networks of specialized regions of skin and cartilage. In skin, collagen XVI is integrated into particularExpand
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