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Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells.
Micronuclei (MN) and other nuclear anomalies such as nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) are biomarkers of genotoxic events and chromosomal instability. These genome damage events… Expand
IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety.
The purpose of these guidelines is to provide concise guidance on the planning, performing and interpretation of studies to monitor groups or individuals exposed to genotoxic agents. Most human… Expand
Report from the In Vitro Micronucleus Assay Working Group
At the Washington International Workshop on Genotoxicity Test Procedures (March 25–26, 1999), the current methodologies and data for the in vitro micronucleus test were reviewed. From this,… Expand
An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.
The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence… Expand
Genotoxicity evaluation of nanosized titanium dioxide, synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes.
- A. Tavares, H. Louro, +9 authors M. Silva
- Chemistry, Medicine
- Toxicology in vitro : an international journal…
- 1 February 2014
Toxicological characterization of manufactured nanomaterials (NMs) is essential for safety assessment, while keeping pace with innovation from their development and application in consumer products.… Expand
What do human micronuclei contain?
As micronuclei (MN) derive from chromosomal fragments and whole chromosomes lagging behind in anaphase, the MN assay can be used to show both clastogenic and aneugenic effects. The distinction… Expand
Chromosomal aberrations and SCEs as biomarkers of cancer risk.
Previous studies have suggested that the frequency of chromosomal aberrations (CAs), but not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined this relationship in… Expand
Cytogenetic biomarkers and genetic polymorphisms.
- H. Norppa
- Biology, Medicine
- Toxicology letters
- 28 September 2003
Cytogenetic biomarkers have long been applied in surveillance of human genotoxic exposure and early effects of genotoxic carcinogens. Due to their wide use, it has been possible to evaluate, in… Expand
Impact of Types of Lymphocyte Chromosomal Aberrations on Human Cancer Risk
The frequency of cells with structural chromosomal aberrations (CAs) in peripheral blood lymphocytes is the first genotoxicity biomarker that has shown an association with cancer risk. CAs are… Expand
Risk assessment of engineered nanomaterials and nanotechnologies--a review.
- K. Savolainen, H. Alenius, H. Norppa, L. Pylkkänen, T. Tuomi, G. Kasper
- Environmental Science, Medicine
- 10 March 2010
With the increasing utilization of engineered nanomaterials (ENM), the potential exposure of workers to ENM is likely to increase significantly. Very little is known though, of the risks posed by ENM… Expand