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An antitumor promoter from Moringa oleifera Lam.
Niazimicin was further subjected to in vivo test and found to have potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as initiator and TPA as tumor promoter. Expand
Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects.
Among the compounds tested, seven compounds on TPA-induced inflammation, and six compounds on EBV-EA activation, exhibited potent inhibitory effects. Expand
Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells
It is shown for the first time that the apoptosis by luteolin is mediated through death receptor 5 (DR5) upregulation, and the possibility that treatment with luteolini might be promising as a new therapy against cancer is raised. Expand
Flavonoids inhibit the expression of heat shock proteins.
It is shown that quercetin and several other flavonoids inhibit the synthesis of hsps induced by heat shock in two human cell lines, Hela cells and COLO320 DM cells. Expand
Triterpene Acids from the Leaves of Perilla frutescens and Their Anti-inflammatory and Antitumor-promoting Effects
Eight triterpene acids isolated from ethanol extracts of the leaves of red and green perilla exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter. Expand
Genistein arrests cell cycle progression at G2-M.
Flow-cytometric analysis and microscopic observation suggest that the G2-M arrest by genistein is a unique effect among flavonoids. Expand
Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
Sesamol seems to be an almost equally potent chemopreventive agent in the promotion stage of cancer development employing the in vitro Epstein-Barr virus early antigen activation assay induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA). Expand
ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients.
It is suggested that the genetic diagnosis of ABCB1 C3435T can be applied to determine MTX sensitivity for the treatment of RA patients, however, further pharmacokinetics studies are required in this regard. Expand
Production of bioactive triterpenes by Eriobotrya japonica calli.
All of the triterpenes isolated from the callus tissues showed an inhibitory effect comparable to (-)-epigallocatechin gallate of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Expand
cDNA microarray analysis of gene expression changes induced by dexamethasone in cultured human trabecular meshwork cells.
PURPOSE To profile gene expression changes induced by dexamethasone in cultured human trabecular meshwork (TM) cells and identify genes related to the occurrence of steroid-induced glaucoma. Expand