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A comparison of gene repair strategies in cell culture using a lacZ reporter system
Synthetic oligonucleotides and DNA fragments of less than 1 kilobase (kb) have been shown to cause site-specific genetic alterations in mammalian cells in culture and in vivo. We have used a lacZ… Expand
The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation
- E. Shang, H. Nickerson, Duancheng Wen, Xiangyuan Wang, D. Wolgemuth
- Medicine, Biology
- 1 October 2007
Brdt is a testis-specific member of the distinctive BET sub-family of bromodomain motif-containing proteins, a motif that binds acetylated lysines and is implicated in chromatin remodeling. Its… Expand
Cyclin A1-deficient mice lack histone H3 serine 10 phosphorylation and exhibit altered aurora B dynamics in late prophase of male meiosis.
Male mice lacking cyclin A1 protein are sterile. Their sterility results from an arrest in the meiotic cell cycle of spermatocytes, which we now identify as occurring at late diplotene, immediately… Expand
Diabetic Complications: Current Challenges and Opportunities
The International Diabetes Federation estimates that 366 million people had diabetes in 2011, and that by 2030, this figure will have risen to a staggering 552 million worldwide. In 2011, diabetes… Expand
Differential Gene Expression in Diabetic Nephropathy in Individuals With Type 1 Diabetes.
- M. Caramori, Y. Kim, +7 authors M. Mauer
- The Journal of clinical endocrinology and…
- 14 April 2015
CONTEXT Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) in the United States. OBJECTIVE The aim of this study was to determine whether there were skin fibroblast… Expand
Variations in Risk of End-Stage Renal Disease and Risk of Mortality in an International Study of Patients With Type 1 Diabetes and Advanced Nephropathy
OBJECTIVE Patients with type 1 diabetes and diabetic nephropathy are targets for intervention to reduce high risk of end-stage renal disease (ESRD) and deaths. This study compares risks of these… Expand
A LacZ-based transgenic mouse for detection of somatic gene repair events in vivo
Somatic gene repair of disease-causing chromosomal mutations is a novel approach for gene therapy. This method would ensure that the corrected gene is regulated by its endogenous promoter and… Expand
Myeloma Cell Lines Are Not Sensitive to Modulation of Cyclin D1 Level.
Dysregulation of D type cyclins is an almost universal event in multiple myeloma. Overexpression of cyclin D1 may occur by chromosomal translocation of t(11:14)(q13:32), and also in association with… Expand
Dysregulation of MMSET Is Tumorigenic In-Vivo.
Approximately 15% of multiple myeloma (MM) is characterized by a t(4;14) translocation that causes the simultaneous dysregulation of MMSET on der(4) and fibroblast growth factor receptor 3 gene… Expand
JDRF perspective: bridging the gap-translational research to prevent progression of diabetic nephropathy.
For those with type 1 diabetes (T1D), the diagnosis of diabetic nephropathy predicts a significant negative impact on quality of life and mortality risk. Diabetic nephropathy is a huge component of… Expand