H. Nick

Publications107
h-index37
Citations4,589
Highly Influential Citations134
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Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide.
Cisplatin is a potent chemotherapeutic agent that is used to treat many human malignancies. Unfortunately, in addition to side effects such as ototoxicity, anaphylaxis, and bone marrow suppression, a… Expand
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Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression.
  • A. Agarwal, H. Nick
  • Biology, Medicine
  • Journal of the American Society of Nephrology…
  • 1 May 2000
Heme oxygenase-1 (HO-1) is a microsomal enzyme involved in the degradation of heme, resulting in the generation of biliverdin, iron, and carbon monoxide. Recent attention has focused on the biologic… Expand
  • 254
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Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response.
We have demonstrated a dramatic induction of manganese superoxide dismutase (Mn-SOD) mRNA levels in response to lipopolysaccharide (LPS), interleukin-1, and tumor necrosis factor in pulmonary… Expand
  • 374
  • 9
Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis.
Heme oxygenase-1 (HO-1) is a 32-kDa microsomal enzyme that catalyzes the conversion of heme to biliverdin, releasing iron and carbon monoxide. Induction of HO-1 occurs as a protective response in… Expand
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Catalytic Properties of Human Manganese Superoxide Dismutase*
The depletion of superoxide catalyzed by human manganese superoxide dismutase (MnSOD) was observed spectrophotometrically by measuring the absorbance of superoxide at 250-280 nm following pulse… Expand
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Manganese superoxide dismutase: a hepatic acute phase protein regulated by interleukin-6 and glucocorticoids.
The superoxide dismutases (SODs) are important metallo-enzymes which scavenge and dismutate the superoxide free radical. They are thought to be the main enzymes in the antioxidant defense system.… Expand
  • 123
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An internal enhancer regulates heme- and cadmium-mediated induction of human heme oxygenase-1.
Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, releasing iron, carbon monoxide, and biliverdin. Induction of HO-1 is an adaptive and beneficial response in renal and… Expand
  • 76
  • 4
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Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements.
The human asparagine synthetase (AS) gene is transcriptionally regulated by amino acid deprivation (amino acid response, AAR) and the endoplasmic reticulum stress response (ERSR), also known as the… Expand
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Amplification of the bacA gene confers bacitracin resistance to Escherichia coli.
An Escherichia coli genomic library was constructed in order to facilitate selection for genes which confer bacitracin resistance through amplification. One of the plasmids from the library, plasmid… Expand
  • 106
  • 4
Smad7-dependent Regulation of Heme Oxygenase-1 by Transforming Growth Factor-β in Human Renal Epithelial Cells*
Heme oxygenase-1 (HO-1), a 32-kDa microsomal enzyme, is induced as a beneficial and adaptive response in cells/tissues exposed to oxidative stress. Transforming growth factor-β1 (TGF-β1) is a… Expand
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