H. Nemoto | Semantic Scholar

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.

Y. Yamazaki, I. Usui, K. Tobe
Biology, Chemistry
American journal of physiology. Endocrinology and…
1 November 2009

SRT1720 treatment may reduce liver lipid accumulation, at least in part, by directly reducing the expressions of lipogenic genes in cultured HepG2 cells.

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Asymmetric synthesis of the four possible fagomine isomers.

H. Takahata, Y. Banba, H. Ouchi, H. Nemoto, A. Kato, I. Adachi
Chemistry
The Journal of organic chemistry
2 April 2003

The asymmetric synthesis of fagomine and its congeners 1-4 has been achieved by catalytic ring-closing metathesis (RCM) by constructing the piperidene-type chiral building block 5 followed by dihydroxylation.

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Marine alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptors.

H. Tsuneki, Y. You, I. Kimura
Biology, Chemistry
Biological & pharmaceutical bulletin
1 April 2005

Since there are few compounds that elicit irreversible blocks of alpha4 beta2 receptors, (-)-pictamine will be a novel, valuable tool to remove the alpha4beta2-nAChR action from neuronal activities mediated by these two major types of nAChRs.

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Synthesis of macrosphelides with a thiazole side chain: new antitumor candidates having apoptosis-inducing property.

Y. Matsuya, T. Kawaguchi, H. Nemoto
Chemistry, Biology
Organic letters
1 September 2006

Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using a ring-closing metathesis (RCM) strategy.…

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Cyclic carbonates, novel expandable monomers on polymerization

T. Takata, F. Sanda, Toshiro Ariga, H. Nemoto, T. Endo
Chemistry
1 June 1997

A variety of cyclic carbonates was shown to undergo volume expansion on polymerization. The degree of volume expansion, which was measured by the density gradient tube method, was ranging from 1.1%…

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Syntheses of aza-analogues of macrosphelides via RCM strategy and their biological evaluation

Kenji Sugimoto, Yuta Kobayashi, Y. Matsuya
Chemistry
7 October 2011

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Novel 3,4-diazabenzotropone compounds (2,3-benzodiazepin-5-ones): synthesis, unique reactivity, and biological evaluation.

Y. Matsuya, Hiroshi Katayanagi, Takuya Ohdaira, Zheng-li Wei, T. Kondo, H. Nemoto
Chemistry
Organic letters
19 March 2009

Novel amine-catalyzed nitrogen extrusion reactions and interesting bioactivities were found to be characteristic of these novel diazabenzotropone compounds, found to exhibit potent apoptosis-inducing activity against human lymphoma cells.

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Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons.

Y. Matsuya, Daisuke Ihara, M. Tsuda
Biology
Bioorganic & medicinal chemistry
15 April 2012

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Asymmetric synthesis of fagomine and its congeners

Y. Banba, Chie Abe, H. Nemoto, A. Kato, I. Adachi, H. Takahata
Chemistry
17 April 2001

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New strategy for the total synthesis of macrosphelides a and B based on ring-closing metathesis.

Y. Matsuya, T. Kawaguchi, H. Nemoto
Chemistry
Organic letters
17 July 2003

A new total synthesis of macrosphelides A and B using ring-closing metathesis (RCM) as a macrocyclization step is described, providing a new effective synthetic route to these natural products.

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