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Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.
- Y. Yamazaki, I. Usui, K. Tobe
- Biology, ChemistryAmerican journal of physiology. Endocrinology and…
- 1 November 2009
SRT1720 treatment may reduce liver lipid accumulation, at least in part, by directly reducing the expressions of lipogenic genes in cultured HepG2 cells.
Asymmetric synthesis of the four possible fagomine isomers.
- H. Takahata, Y. Banba, H. Ouchi, H. Nemoto, A. Kato, I. Adachi
- ChemistryThe Journal of organic chemistry
- 2 April 2003
The asymmetric synthesis of fagomine and its congeners 1-4 has been achieved by catalytic ring-closing metathesis (RCM) by constructing the piperidene-type chiral building block 5 followed by dihydroxylation.
Marine alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptors.
Since there are few compounds that elicit irreversible blocks of alpha4 beta2 receptors, (-)-pictamine will be a novel, valuable tool to remove the alpha4beta2-nAChR action from neuronal activities mediated by these two major types of nAChRs.
Synthesis of macrosphelides with a thiazole side chain: new antitumor candidates having apoptosis-inducing property.
Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using a ring-closing metathesis (RCM) strategy.…
Cyclic carbonates, novel expandable monomers on polymerization
A variety of cyclic carbonates was shown to undergo volume expansion on polymerization. The degree of volume expansion, which was measured by the density gradient tube method, was ranging from 1.1%…
Syntheses of aza-analogues of macrosphelides via RCM strategy and their biological evaluation
Novel 3,4-diazabenzotropone compounds (2,3-benzodiazepin-5-ones): synthesis, unique reactivity, and biological evaluation.
- Y. Matsuya, Hiroshi Katayanagi, Takuya Ohdaira, Zheng-li Wei, T. Kondo, H. Nemoto
- ChemistryOrganic letters
- 19 March 2009
Novel amine-catalyzed nitrogen extrusion reactions and interesting bioactivities were found to be characteristic of these novel diazabenzotropone compounds, found to exhibit potent apoptosis-inducing activity against human lymphoma cells.
Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons.
Asymmetric synthesis of fagomine and its congeners
New strategy for the total synthesis of macrosphelides a and B based on ring-closing metathesis.
A new total synthesis of macrosphelides A and B using ring-closing metathesis (RCM) as a macrocyclization step is described, providing a new effective synthetic route to these natural products.