Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis.
The SSRIs or SNRIs, clonidine, and gabapentin trials provide evidence for efficacy; however, effects are less than for estrogen, few trials have been published and most have methodological deficiencies, generalizability is limited, and adverse effects and cost may restrict use for many women.
Screening for Breast Cancer: An Update for the U.S. Preventive Services Task Force
- H. Nelson, K. Tyne, A. Naik, C. Bougatsos, B. Chan, L. Humphrey
- MedicineAnnals of Internal Medicine
- 17 November 2009
New studies and evidence gaps that were unresolved at the time of the 2002 USPSTF recommendation are focused on, including the effectiveness of mammography screening in decreasing breast cancer mortality among average-risk women aged 40 to 49 years and 70 years or older.
Postmenopausal hormone replacement therapy: scientific review.
Benefits of HRT include prevention of osteoporotic fractures and colorectal cancer, while prevention of dementia is uncertain, according to a meta-analysis of 22 estrogen trials, cohort studies, results of the WHI, and trials with bone density outcomes.
Physicians' experiences with the Oregon Death with Dignity Act.
- L. Ganzini, H. Nelson, T. Schmidt, D. Kraemer, M. Delorit, M. Lee
- MedicineThe New England journal of medicine
- 24 February 2000
It is indicated that in Oregon, physicians grant about 1 in 6 requests for a prescription for a lethal medication and that 1 in 10 requests actually result in suicide.
Effectiveness of Breast Cancer Screening: Systematic Review and Meta-analysis to Update the 2009 U.S. Preventive Services Task Force Recommendation
- H. Nelson, Rochelle Fu, A. Cantor, M. Pappas, M. Daeges, L. Humphrey
- MedicineAnnals of Internal Medicine
- 16 February 2016
This systematic review updates evidence for the USPSTF on the effectiveness of mammography screening in reducing breast cancer mortality, all-cause mortality, and advanced breast cancer for women at average risk and how effectiveness varies by age, risk factors, screening intervals, and imaging modalities.
Hormone replacement therapy and cognition: systematic review and meta-analysis.
In women with menopausal symptoms, HRT may have specific cognitive effects, and future studies should target these effects, although possible biases and lack of control for potential confounders limit interpretation of these studies.
Screening for Speech and Language Delay in Preschool Children: Systematic Evidence Review for the US Preventive Services Task Force
The strengths and limits of evidence about the effectiveness of screening and interventions for speech and language delay in preschool-aged children are evaluated to determine the balance of benefits and adverse effects of routine screening in primary care for the development of guidelines by the US Preventive Services Task Force.
Diagnostic concordance among pathologists interpreting breast biopsy specimens.
In this study of pathologists, in which diagnostic interpretation was based on a single breast biopsy slide, overall agreement between the individual pathologists' interpretations and the expert consensus-derived reference diagnoses was 75.3%, with the highest level of concordance for invasive carcinoma and lower levels of concords for DCIS and atypia.
Risk Factors for Breast Cancer for Women Aged 40 to 49 Years
Extremely dense breasts and first-degree relatives with breast cancer were each associated with at least a 2-fold increase in risk for breast cancer in women aged 40 to 49 years, which may be useful for personalized mammography screening.
Screening Women for Intimate Partner Violence: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation
Screening women for IPV can provide benefits that vary by population, while potential adverse effects have minimal effect on most women, and screening instruments accurately identify women experiencing IPV.