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Cloning and expression of a rat brain GABA transporter.
TLDR
Hydropathy analysis of the deduced protein suggests multiple transmembrane regions, a feature shared by several cloned transporters; however, database searches indicate that GAT-1 is not homologous to any previously identified proteins.
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Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain.
TLDR
Specific localization of the taurine/beta-alanine transporter in mouse brain suggests a potential function for taurines and beta-alanines as neurotransmitters.
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Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected].
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Cloning and expression of a spinal cord- and brain-specific glycine transporter with novel structural features.
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A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.
TLDR
Results suggest that Smf1p is involved in high-affinity Mn2+ uptake and suggests that in vivo Mas1P is a manganese-dependent peptidase, and resembles a protein from Drosophila and mammalian macrophages.
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Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethality.
TLDR
Failure to lower the pH in the vacuolar system of yeast, and probably other eukaryotic cells, is lethal and the mutants may survive only if a low external pH allows for this acidification by fluid-phase endocytosis.
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Molecular Characterization of Four Pharmacologically Distinct a-Aminobutyric Acid Transporters in Mouse Brain *
TLDR
Two novel y-aminobutyric acid (GABA) transporters, GAT3 and GAT4, were cloned from the mouse neonatal brain cDNA library and expressed in Xenopus oocytes, suggesting functional specialization in the mechanisms of GABA transmission termination.
Metal ions suppress the abnormal taste behavior of the Drosophila mutant malvolio.
TLDR
The suppression of the defective taste behavior suggests that MVL functions as a Mn2+/Fe2+ transporter and that Mn2 and/or Fe2+ are involved in the signal transduction of taste perception in Drosophila adults.
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A Novel Family of Yeast Chaperons Involved in the Distribution of V-ATPase and Other Membrane Proteins*
TLDR
A novel gene family in which null mutations cause pleiotropic effects on metal-ion resistance or sensitivity and distribution of membrane proteins in different targets was discovered and may provide an explanation for the svf phenotype in the double disruptant mutants of ΔVTC1 and ΔVMAsubunits.
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Expression of a mouse brain cDNA encoding novel gamma-aminobutyric acid transporter.
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