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Development of specific Rho-kinase inhibitors and their clinical application.
- M. Tamura, H. Nakao, +6 authors H. Hidaka
- Chemistry, Medicine
- Biochimica et biophysica acta
- 30 December 2005
Hexahydro-1-(isoquinoline-5-sulfonyl)-1H-1,4-diazepine, HA-1077, is a known selective inhibitor of Rho-kinase. Although its IC(50) value against Rho-kinase is more than 10 times lower than those for… Expand
Preparation of undegraded native molecular fibroin solution from silkworm cocoons
Abstract The molecular mass of solubilized fibroin prepared from silk was analyzed by SDS-PAGE. It was found that the fibroin molecule was degraded during reeling, degumming (removal of sericin), and… Expand
An insight into the role of barrier related skin proteins.
- Kiyomi Wato, T. Hara, Kenjirou Yamana, H. Nakao, Toshio Inagi, K. Terada
- Chemistry, Medicine
- International journal of pharmaceutics
- 10 May 2012
It is well-known that intercellular lipids in the stratum corneum (SC) of the skin play an important role in maintaining barrier function, and many types of penetration enhancers affecting lipids are… Expand
L-2,4-diaminobutyric acid decarboxylase activity responsible for the formation of 1,3-diaminopropane in Enterobacter aerogenes.
High content of l-2,4-diaminopropane (DAP), a normally minor derivative of polyamine metabolism, have been observed in cells of Enterobacteraerogenes. Supplementation of the growth medium with… Expand
The presence of l-2,4-diaminobutyric acid decarboxylase activity in Vibrio species: A new biosynthetic pathway for 1,3-diaminopropane
A new enzyme activity, which catalyzes decarboxylation of l-2,4-diaminobutyric acid (DABA) to yield 1,3-diaminopropane (DAP), has been found in dialyzed crude extracts prepared from Vibrio… Expand
Purification and properties of carboxynorspermidine decarboxylase, a novel enzyme involved in norspermidine biosynthesis, from Vibrio alginolyticus
Summary: A novel enzyme which catalyses the decarboxylation of carboxynorspermidine [H2N(CH2)3NHCH2CH2-CH(NH2)COOH] to yield norspermidine [H2N(CH2)3NH2], one of the unusual polyamines, was purified… Expand
Defensive effects of human antimicrobial peptide α-defensins against Enterococcus faecalis.
Cationic and amphiphilic antimicrobial peptides (AMPs) such as α-defensins and cathelicidins are factors related to innate immunity. In the present study, we examined the protective effects of two… Expand
Novel bismaleimide/diallylbisphenol A resin modified with multifunctional thiol containing isocyanuric ring and long-chain aliphatic unit
4,4′-Diphenylmethane bismaleimide (BMI)/2,2′-diallylbisphenol A (DABPA) resin was modified with a multifunctional thiol containing isocyanuric ring and long-chain aliphatic unit… Expand
Pressure vessel plates, high strength steels for intermediate and moderate temperature service
Specifications japonaises pour ces aciers pouvant etre utilises a partir de la temperature ambiante jusqu'a 400 C et etre substitues aux aciers a 0,5% Mo. Equilibre des elements microallies assurant… Expand