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Development of specific Rho-kinase inhibitors and their clinical application.
Hexahydro-1-(isoquinoline-5-sulfonyl)-1H-1,4-diazepine, HA-1077, is a known selective inhibitor of Rho-kinase. Although its IC(50) value against Rho-kinase is more than 10 times lower than those forExpand
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Preparation of undegraded native molecular fibroin solution from silkworm cocoons
Abstract The molecular mass of solubilized fibroin prepared from silk was analyzed by SDS-PAGE. It was found that the fibroin molecule was degraded during reeling, degumming (removal of sericin), andExpand
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An insight into the role of barrier related skin proteins.
It is well-known that intercellular lipids in the stratum corneum (SC) of the skin play an important role in maintaining barrier function, and many types of penetration enhancers affecting lipids areExpand
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L-2,4-diaminobutyric acid decarboxylase activity responsible for the formation of 1,3-diaminopropane in Enterobacter aerogenes.
High content of l-2,4-diaminopropane (DAP), a normally minor derivative of polyamine metabolism, have been observed in cells of Enterobacteraerogenes. Supplementation of the growth medium withExpand
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The presence of l-2,4-diaminobutyric acid decarboxylase activity in Vibrio species: A new biosynthetic pathway for 1,3-diaminopropane
A new enzyme activity, which catalyzes decarboxylation of l-2,4-diaminobutyric acid (DABA) to yield 1,3-diaminopropane (DAP), has been found in dialyzed crude extracts prepared from VibrioExpand
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Purification and properties of carboxynorspermidine decarboxylase, a novel enzyme involved in norspermidine biosynthesis, from Vibrio alginolyticus
Summary: A novel enzyme which catalyses the decarboxylation of carboxynorspermidine [H2N(CH2)3NHCH2CH2-CH(NH2)COOH] to yield norspermidine [H2N(CH2)3NH2], one of the unusual polyamines, was purifiedExpand
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Defensive effects of human antimicrobial peptide α-defensins against Enterococcus faecalis.
Cationic and amphiphilic antimicrobial peptides (AMPs) such as α-defensins and cathelicidins are factors related to innate immunity. In the present study, we examined the protective effects of twoExpand
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  • Open Access
Novel bismaleimide/diallylbisphenol A resin modified with multifunctional thiol containing isocyanuric ring and long-chain aliphatic unit
4,4′-Diphenylmethane bismaleimide (BMI)/2,2′-diallylbisphenol A (DABPA) resin was modified with a multifunctional thiol containing isocyanuric ring and long-chain aliphatic unitExpand
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Pressure vessel plates, high strength steels for intermediate and moderate temperature service
Specifications japonaises pour ces aciers pouvant etre utilises a partir de la temperature ambiante jusqu'a 400 C et etre substitues aux aciers a 0,5% Mo. Equilibre des elements microallies assurantExpand