• Publications
  • Influence
Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis.
Afadin is an actin filament-binding protein that binds to nectin, an immunoglobulin-like cell adhesion molecule, and is colocalized with nectin at cadherin-based cell-cell adherens junctions (AJs).Expand
  • 280
  • 8
Dimerumic acid as an antioxidant of the mold, Monascus anka.
We previously reported that the mold Monascus anka, traditionally used for fermentation of food, showed antioxidant and hepatoprotective actions against chemically induced liver injuries. In theExpand
  • 108
  • 8
Leptomeningeal cells activate microglia and astrocytes to induce IL-10 production by releasing pro-inflammatory cytokines during systemic inflammation
The leptomeninges covering the surface of the brain parenchyma play the physical role at the cerebrospinal fluid-blood barrier. We report here that leptomeningeal cells may transduce peripheralExpand
  • 76
  • 6
  • PDF
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice
To understand the mechanisms of retinal atrophy in cathepsin D-deficient mice, the postnatal development of their retinae was analyzed. TUNEL-positive cells appeared abundantly in the outer nuclearExpand
  • 133
  • 4
  • PDF
Reverse of Age-Dependent Memory Impairment and Mitochondrial DNA Damage in Microglia by an Overexpression of Human Mitochondrial Transcription Factor A in Mice
Mitochondrial DNA (mtDNA) is highly susceptible to injury induced by reactive oxygen species (ROS). During aging, mutations of mtDNA accumulate to induce dysfunction of the respiratory chain,Expand
  • 128
  • 4
  • PDF
Microglial functions and proteases
  • H. Nakanishi
  • Medicine, Biology
  • Molecular Neurobiology
  • 1 April 2003
There is accumulating evidence that intracellular and extracellular proteases of microglia contribute to various events in the central nervous system (CNS) through both nonspecific and limitedExpand
  • 131
  • 4
  • PDF
Neuronal and microglial cathepsins in aging and age-related diseases
  • H. Nakanishi
  • Medicine, Biology
  • Ageing Research Reviews
  • 1 October 2003
It has been long believed that cathepsins compensate for each other because of their overlapping substrate specificities. However, there is increasing evidence that disturbance of the normal balanceExpand
  • 102
  • 4
  • PDF
Frequent p53 accumulation in the chronically sun-exposed epidermis and clonal expansion of p53 mutant cells in the epidermis adjacent to basal cell carcinoma.
p53 expression was studied immunohistochemically to identify a precursor lesion of basal cell carcinoma (BCC) in the epidermis adjacent to BCC. With two different anti-p53 antibodies of CM1 and DO7,Expand
  • 72
  • 4
Age-dependent responses of glial cells and leptomeninges during systemic inflammation
Systemic inflammation causes the age-dependent differential glial responses, but little is known about how age influences the barrier function of leptomeninges during systemic inflammation. ThisExpand
  • 45
  • 4
  • PDF
alpha-catenin-independent recruitment of ZO-1 to nectin-based cell-cell adhesion sites through afadin.
ZO-1 is an actin filament (F-actin)-binding protein that localizes to tight junctions and connects claudin to the actin cytoskeleton in epithelial cells. In nonepithelial cells that have no tightExpand
  • 88
  • 3