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Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)‐β and bone morphogenetic protein (BMP)
- Y. Nakajima, T. Yamagishi, S. Hokari, H. Nakamura
- Biology, Medicine
- The Anatomical record
- 1 February 2000
Endothelial‐mesenchymal transformation (EMT) is a critical event in the generation of the endocardial cushion, the primordia of the valves and septa of the adult heart. This embryonic phenomenon… Expand
Redox regulation of cellular activation.
Growing evidence has indicated that cellular reduction/oxidation (redox) status regulates various aspects of cellular function. Oxidative stress can elicit positive responses such as cellular… Expand
Role of Pax‐5 in the regulation of a mid‐hindbrain organizer’s activity
- J. Funahashi, T. Okafuji, H. Ohuchi, S. Noji, H. Tanaka, H. Nakamura
- Biology, Medicine
- Development, growth & differentiation
- 1 February 1999
The mes‐metencephalic boundary (isthmus) has been suggested to act as an organizer in the development of the optic tectum. Pax‐5 was cloned as a candidate for regulator of the organizing center.… Expand
Angioscopic evaluation of coronary-artery thrombi in acute coronary syndromes.
- K. Mizuno, K. Satomura, +6 authors J. Ambrose
- The New England journal of medicine
- 30 January 1992
BACKGROUND Disruption of an atherosclerotic plaque in a coronary artery followed by the formation of a thrombus is believed to be the cause of both unstable angina and acute myocardial infarction.… Expand
Development of pharyngeal arch arteries in early mouse embryo
The formation and transformation of the pharyngeal arch arteries in the mouse embryo, from 8.5 to 13 days of gestation (DG), was observed using scanning electron microscopy of vascular casts and… Expand
Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases.
- H. Nakamura, Y. Fujii, E. Ohuchi, E. Yamamoto, Y. Okada
- Chemistry, Medicine
- European journal of biochemistry
- 1 April 1998
Matrix metalloproteinases (MMP) are synthesized as inactive zymogens (proMMP) and subsequently activated by many factors to degrade the extracellular matrix (ECM). In the present study, we have… Expand
Oxford phase 3 unicompartmental knee arthroplasty in Japan--clinical results in greater than one thousand cases over ten years.
- K. Yoshida, M. Tada, H. Yoshida, S. Takei, Shinichi Fukuoka, H. Nakamura
- The Journal of arthroplasty
- 1 October 2013
There are few reports of the Oxford unicompartmental knee arthroplasty (UKA) survival rate in Asia. This study describes outcomes of 1279 Oxford UKAs for Japanese patients. The mean follow-up was 5.2… Expand
Bone morphogenetic protein‐2 acts synergistically with transforming growth factor‐β3 during endothelial‐mesenchymal transformation in the developing chick heart
- T. Yamagishi, Y. Nakajima, K. Miyazono, H. Nakamura
- Biology, Medicine
- Journal of cellular physiology
- 1 July 1999
In the early embryonic heart, endothelial cells in atrioventricular (AV) and outflow tract (OT) regions are transformed into the invasive mesenchymal cells that form endocardial cushion tissue… Expand
Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors.
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors prevent the conversion of HMG-CoA to mevalonate and thereby inhibit the synthesis of other products derived from this metabolite.… Expand
Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production.
CD44, an adhesion molecule that binds to the extracellular matrix, primarily to hyaluronan (HA), has been implicated in cancer cell migration, invasion, and metastasis. CD44 has also recently been… Expand