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Efficacy and safety of bortezomib plus dexamethasone therapy for refractory or relapsed multiple myeloma: once-weekly administration of bortezomib may reduce the incidence of gastrointestinal adverse…
BACKGROUND To establish the clinical use of bortezomib with fewer adverse events, we retrospectively analyzed the efficacy and safety of bortezomib plus dexamethasone (BD) therapy for relapsed or… Expand
Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation.
- H. Nakajima, Y. Ishigaki, +15 authors Y. Motoo
- Medicine, Biology
- International journal of oncology
- 1 September 2010
The Family with sequence similarity 107 (FAM107) possesses an N-terminal domain of unknown function (DUF1151) that is highly conserved beyond species. In human, FAM107A termed TU3A/DRR1 has been… Expand
Daily 500 mg valacyclovir is effective for prevention of Varicella zoster virus reactivation in patients with multiple myeloma treated with bortezomib.
BACKGROUND In patients with multiple myeloma (MM), bortezomib is associated with a significant risk of Varicella zoster virus (VZV) reactivation. There are some reports that acyclovir reduces the… Expand
Cisplatin augments FAS-mediated apoptosis through lipid rafts.
- Cheng-Ri Huang, Zhe-Xiong Jin, +15 authors H. Umehara
- Biology, Medicine
- Anticancer research
- 1 June 2010
Cisplatin is widely and effectively used for the treatment of various types of cancer. However, its biochemical mechanisms are still unelucidated. Previously, we reported that membrane sphingomyelin… Expand
Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine
BackgroundPancreatic cancer is obstinate and resistant to gemcitabine, a standard chemotherapeutic agent for the disease. We previously showed a therapeutic effect of glycogen synthase kinase-3β… Expand
Experimental Lung Cancer produced in Dogs by intrabronchial Application of 20-methylcholanthrene
我々は雑種成犬10頭に蒸留水2.5ccに溶解した20-methylcholanthrene 100mgを, 気管支鏡下に右下葉支末梢に週1回注入した. 10例中7例に肺癌が発生したが, 注入期間は2年11ヶ月から3年10ヶ月, 20-MCの総量は12.49から19.49であった. 腫瘍の形態は孤立結節型6例, 浸潤型1例で, 組織型は腺癌3例, 扁平上皮癌2例および両者の混合型2例である.… Expand
CT Assisted Stereotactic Biopsy of Deep Cerebral Lesions and the Results
Various methods for CT assisted stereotactic biopsy of deep seated cerebral lesions have been reported on. We here describe our simple method of stereotactic biopsy and the results of long term… Expand
Significance of Carcinoembryonic Antigen (CEA) Level Determination in Drainage Venous Blood in Predicting Liver Metastases of Colorectal Cancer
Family with sequence similarity 107: A family of stress responsive small proteins with diverse functions in cancer and the nervous system (Review)
Under conditions of acute stress, rapid adaptation is crucial for maximizing biological survival. The responses to environmental stress are often complex, involving numerous genes and integrating… Expand
Serotonin induces the migration of PC12 cells via the serotonin receptor 6/cAMP/ERK pathway.
Serotonin (5-HT) functions as a chemoattractant that modulates neural migration during prenatal and early postnatal development. However, its molecular mechanism remains to be elucidated. The effect… Expand