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Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo
It is described, at the molecular level, for the first time, that pharmacological Sig-1R activation enhances the autophagic flux in human cells and in Caenorhabditis elegans and increases proteostasis capacity, ultimately ameliorating paralysis caused by protein aggregation in C. elegans. Expand
Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
It is indicated that CB1 deficiency can worsen AD-related cognitive deficits and support a potential role of CB1 as a pharmacologic target. Expand
The cleavage product of amyloid-β protein precursor sAβPPα modulates BAG3-dependent aggresome formation and enhances cellular proteasomal activity.
It is demonstrated that sAβPPα modulates Bag3 expression, aggresome formation, and proteasomal activity, thereby providing first evidence for a function of sA βPPα in the regulation of proteostasis. Expand
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress
Interestingly, increased expression of functional ADAM10 above the endogenous level did not correlate with a better protection against seizures and neurodegeneration, and additional cleavage products of ADAM 10 may counterbalance the neuroprotective effect of alpha-secretase-cleaved APP in the defense against excitotoxicity. Expand
In Vitro Phosphorylation in Isolated Horizontal Cells of the Fish Retina: Effects of the State of Light Adaptation
It is revealed that horizontal cells of the fish retina contain cyclic AMP‐, calcium/calmodulin‐ and calcium/phospholipid‐dependent protein kinase activity resulting in the phosphorylation of several horizontal cell proteins, including the phosphoproteins which were affected by the state of light adaptation. Expand
BAG3 Proteomic Signature under Proteostasis Stress
The multifunctionality of BAG3 is confirmed and its crucial role in diverse cellular signaling pathways and processes is highlighted, ensuring cellular proteostasis and cell viability. Expand