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Induction of Sister Chromatid Exchanges by Extremely Low Doses of α-Particles
TLDR
Results indicate that genetic damage may be induced by low doses of alpha-radiation in cell nuclei not actually traversed by an alpha-particle in hamster ovary cells irradiated with plutonium-238 source. Expand
Induction of sister chromatid exchanges by extremely low doses of alpha-particles.
TLDR
Results indicate that genetic damage may be induced by low doses of alpha-radiation in cell nuclei not actually traversed by an alpha-particle in hamster ovary cells irradiated with plutonium-238 source. Expand
Ku70: a candidate tumor suppressor gene for murine T cell lymphoma.
TLDR
It is shown that Ku70 deficiency facilitates neoplastic growth and a novel role of the Ku70 locus in tumor suppression is suggested, which is thought to be related to B but not T lymphocyte maturation. Expand
Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect.
TLDR
The data are consistent with the conclusion that the enhanced efficiency of each nuclear traversal at low particle fluences is the result of mutations arising in nonirradiated, bystander cells. Expand
Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles.
TLDR
The hypothesis that the primary DNA damage in bystander CHO cells is oxidative base damage leading to a relatively small bystander effect for gross chromosomal aberrations as compared with mutations or SCE is discussed; the larger bystanderser effect in xrs-5 cells is the result of oxidative damage and non-repaired DNA strand breaks which may result from opposed oxidative lesions. Expand
Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation.
TLDR
In low-passage normal human fibroblasts, siRNA knock-down of DNA-PKcs resulted in a reduced capacity for restitution of radiation-induced interphase chromosome breaks as measured by premature chromosome condensation, an increased yield of acentric chromosome fragments at the first postirradiation mitosis, and an increased radiosensitivity for cell killing. Expand
Involvement of the Nonhomologous End Joining DNA Repair Pathway in the Bystander Effect for Chromosomal Aberrations
TLDR
It is hypothesize that the marked sensitization of repair-deficient bystander cells to the induction of chromosomal aberrations is a consequence of unrejoined DNA double-strand breaks occurring as a result of clustered damage arising from opposed oxidative lesions and single- Strand breaks. Expand
Repression of mutagenesis by Rad51D-mediated homologous recombination
TLDR
Results confirm the a priori expectation that HRR acts in an error-free manner to repress three classes of genetic alterations (chromosomal aberrations, loss of gene function and increased gene expression), all of which are associated with carcinogenesis. Expand
Radiation-induced genomic instability: delayed mutagenic and cytogenetic effects of X rays and alpha particles.
TLDR
The results suggest that among clones showing a high frequency of delayed mutations there may be a subpopulation of cells that are particularly unstable; selection for the slow-growth phenotype has the effect of selecting for this chromosomally unstable subpopulation. Expand
CDC2 is down-regulated by ionizing radiation in a p53-dependent manner.
TLDR
It is shown that cdc2 mRNA and protein are down-regulated after irradiation of normal human and mouse fibroblasts with doses as low as 0.5 Gy and that this down-regulation is p53-dependent and involves the cyclin-dependent kinase inhibitor p21Waf1 as a negative factor in the control of CDC2 expression. Expand
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