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Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 A.
The structure of pyruvate kinase (EC 2.7.1.40) has been determined from a 2.6 A resolution electron density map. This map shows more detail than the previous 3.1 A map (Stammers & Muirhead, 1977) andExpand
The structure of cat muscle pyruvate kinase.
The complete amino acid sequence of cat muscle pyruvate kinase has been determined and fitted to the 2.6 A resolution electron density map. Residues in the active site region are highly conserved inExpand
Design and synthesis of new enzymes based on the lactate dehydrogenase framework.
Analysis of the mechanism and structure of lactate dehydrogenases is summarized in a map of the catalytic pathway. Chemical probes, single tryptophan residues inserted at specific sites and a crystalExpand
Structure of a ternary complex of an allosteric lactate dehydrogenase from Bacillus stearothermophilus at 2.5 A resolution.
We report the refined structure of a ternary complex of an allosterically activated lactate dehydrogenase, including the important active site loop. Eightfold non-crystallographic symmetry averagingExpand
Structure Of Hæemoglobin: A Three-Dimensional Fourier Synthesis of Reduced Human Haemoglobin at 5.5 Å Resolution
Structure Of Haeemoglobin: A Three-Dimensional Fourier Synthesis of Reduced Human Haemoglobin at 5.5 A Resolution
A specific, highly active malate dehydrogenase by redesign of a lactate dehydrogenase framework.
Three variations to the structure of the nicotinamide adenine dinucleotide (NAD)-dependent L-lactate dehydrogenase from Bacillus stearothermophilus were made to try to change the substrateExpand
Three-dimensional Fourier Synthesis of Horse Oxyhaemoglobin at 2.8 Å Resolution: The Atomic Model
The secondary structure of the haemoglobin chains is similar to that of myoglobin, but some of the helical segments are more irregular and some parts of the non-helical segments have differentExpand
The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia.
Phosphoglucose isomerase (PGI) is a multifunctional protein, which, inside the cell, functions as a housekeeping enzyme of glycolysis and gluconeogenesis and, outside the cell, exerts whollyExpand
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